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Substance Name: Loxoprofen
RN: 80382-23-6
UNII: NDC2M7399S
InChIKey: WORCCYVLMMTGFR-UHFFFAOYSA-M

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Molecular Formula

  • C15-H17-O3.Na.2H2-O

Molecular Weight

  • 268.2863
 
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Names and Synonyms

Name of Substance

  • Loxoprofen

Synonyms

  • alpha-Methyl-4-((2-oxocyclopentyl)methyl)benzeneacetate sodium salt dihydrate
  • CS-600
  • Loxoprofen sodium dihydrate
  • Sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate dihydrate
  • UNII-NDC2M7399S

Systematic Name

  • Benzeneacetic acid, alpha-methyl-4-((2-oxocyclopentyl)methyl)-, sodium salt, dihydrate

Registry Numbers

CAS Registry Number

  • 80382-23-6

FDA UNII

  • NDC2M7399S

System Generated Number

  • 0080382236

Molecular Formulas

Molecular Formula

  • C15-H17-O3.Na.2H2-O

Molecular Formula Fragments

  • C15-H17-O3
  • COMPONENT
  • H2-O
  • Na

Structure Descriptors

InChI

1S/C15H18O3.Na/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);/q;+1/p-1

InChIKey

WORCCYVLMMTGFR-UHFFFAOYSA-M

Smiles

CC(c1ccc(cc1)CC2CCCC2=O)C(=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 857ug/kg (0.857mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 333, 1993.
mouse LD50 intraperitoneal 1020mg/kg (1020mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
mouse LD50 intravenous 740mg/kg (740mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
mouse LD50 oral 3030mg/kg (3030mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
mouse LD50 subcutaneous 1070mg/kg (1070mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat LD50 intraperitoneal 245mg/kg (245mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat LD50 intravenous 155mg/kg (155mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat LD50 oral 145mg/kg (145mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.
rat LD50 subcutaneous 285mg/kg (285mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 36, Pg. 1, 1984.