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Substance Name: Levoleucovorin calcium [USAN]
RN: 80433-71-2
UNII: 778XL6VBS8
InChIKey: KVUAALJSMIVURS-QNTKWALQSA-L

Note

  • The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid. /levoleucovorin is the active stereoisomer/

Molecular Formula

  • C20-H21-Ca-N7-O7

Molecular Weight

  • 511.5059
 

Classification Codes

  • Antidote (to Folic Acid Antagonists)
  • Antidotes
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Names and Synonyms

Name of Substance

  • Calcium levofolinate [INN]
  • Folinic acid l-form calcium salt
  • Levoleucovorin calcium [USAN]

Synonyms

  • Calcium levofolinate
  • Calcium N-(p-((((6S)-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)
  • CL 307,782
  • Elvorine
  • Fusilev
  • Isovorin
  • L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), (S)-
  • Levoleucovorin calcium
  • UNII-778XL6VBS8

Systematic Name

  • L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), (S)-

Registry Numbers

CAS Registry Number

  • 80433-71-2

FDA UNII

  • 778XL6VBS8

System Generated Number

  • 0080433712

Structure Descriptors

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12-,13-;/m0./s1

InChIKey

KVUAALJSMIVURS-QNTKWALQSA-L

Smiles

c12N([C@H](CNc1[nH]c(nc2=O)N)CNc1ccc(cc1)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])C=O.[Ca+2]