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Substance Name: Isomerase, deoxyribonucleate topo-
RN: 80449-01-0


  • DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
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Names and Synonyms


  • DNA topoisomerase I
  • DNA Topoisomerase I, calf thymus
  • DNA Topoisomerase II, calf thymus
  • Topoisomerase I
  • Topoisomerase I, calf thymus
  • Topoisomerase I, hl-60 cell
  • Topoisomerase I, human
  • Topoisomerase I, L1210 cell
  • Topoisomerase II, calf thymus
  • Topoisomerase II, human

Systematic Name

  • Isomerase, deoxyribonucleate topo-

Registry Numbers

CAS Registry Number

  • 80449-01-0

System Generated Number

  • 0080449010