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Substance Name: Fluticasone propionate [USAN:USP]
RN: 80474-14-2
UNII: O2GMZ0LF5W
InChIKey: WMWTYOKRWGGJOA-CENSZEJFSA-N

Note

  • Used in nasal spray for seasonal allergic rhinitis.

Molecular Formula

  • C25-H31-F3-O5-S

Molecular Weight

  • 500.5749
 

Classification Codes

  • Anti-Inflammatory
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Fluticasone propionate [USAN:USP]

Synonyms

  • ArmonAir RespiClick
  • Asmatil
  • Atemur
  • Axotide
  • Brethal
  • CCI 18781
  • Cultivate
  • Cutivate
  • Flixonase
  • Flixonase Nasal Spray
  • Flixotide
  • Flixotide Disk
  • Flixotide Disks
  • Flixotide Inhaler
  • Flonase
  • Flonase Allergy Relief
  • Flonase Aq
  • Flovent
  • Flovent Diskus
  • Flovent Diskus 100
  • Flovent Diskus 250
  • Flovent Diskus 50
  • Flovent HFA
  • Flovent-hfa
  • Fluinol
  • Flunase
  • Flusonal
  • Fluspiral
  • Fluticasone propionate
  • Fluticasonpropionat Allen
  • Flutide
  • Flutivate
  • Inalacor
  • Rinosone
  • S-(Fluoromethyl) 6alpha,9-difluoro-11beta,17-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate, 17-propionate
  • Trialona
  • Ubizol
  • UNII-O2GMZ0LF5W
  • Xhance
  • Zoflut

Systematic Name

  • Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, (6alpha,11beta,16alpha,17alpha)-S-(fluoromethyl) ester

Superlist Name

  • Fluticasone propionate

Registry Numbers

CAS Registry Number

  • 80474-14-2

FDA UNII

  • O2GMZ0LF5W

System Generated Number

  • 0080474142

Structure Descriptors

InChI

1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

InChIKey

WMWTYOKRWGGJOA-CENSZEJFSA-N

Smiles

CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LC inhalation > 40770ug/m3/1 (40.77mg/m3) CARDIAC: CHANGES IN HEART WEIGHT Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20, Pg. 1501, 1992.
rat LD50 oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20, Pg. 1493, 1992.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

ENDOCRINE: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20, Pg. 1493, 1992.