Substance Name: Pancreatin [USP:BAN:JAN]
RN: 8049-47-6
Note
- A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction.
Molecular Formula
- Unspecified
Classification Codes
- Drug / Therapeutic Agent
- Enzyme (Digestant Adjunct)
- Gastrointestinal Agents
- TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Links to Resources
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Names and Synonyms
Name of Substance
- Pancreatin
- Pancreatin [USP:BAN:JAN]
MeSH Heading
- Pancreatin
Synonyms
- Beef viokase
- Diastase vera
- EINECS 232-468-9
- HSDB 1976
- Ilozyme
- Intrazyme
- Norzyme
- Pancreatic enzymes
- Pancreatic extract
- Pancreatin
- Pancrex-V
- Pankreon
- Pankrotanon
- Panteric
- Viobin
- Viokase
- Zypanar
Systematic Name
- Pancreatin
Superlist Name
- Pancreatin
Mixture Names
- Donnazyme
- Entozyme
- Stamyl
Registry Numbers
CAS Registry Number
- 8049-47-6
Other Registry Numbers
- 388123-90-8
- 8057-43-0
- 9002-16-8
- 9046-39-3
System Generated Number
- 0008049476
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 2100mg/kg (2100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. | |
| mouse | LD50 | subcutaneous | 3870mg/kg (3870mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. |
| rat | LD50 | intraperitoneal | 2550mg/kg (2550mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. | |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. | |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975. |