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Substance Name: Pancreatin [USP:BAN:JAN]
RN: 8049-47-6

Note

  • A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme (Digestant Adjunct)
  • Gastrointestinal Agents
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)

Names and Synonyms

Name of Substance

  • Pancreatin
  • Pancreatin [USP:BAN:JAN]

MeSH Heading

  • Pancreatin

Synonyms

  • Beef viokase
  • Diastase vera
  • EINECS 232-468-9
  • HSDB 1976
  • Ilozyme
  • Intrazyme
  • Norzyme
  • Pancreatic enzymes
  • Pancreatic extract
  • Pancreatin
  • Pancrex-V
  • Pankreon
  • Pankrotanon
  • Panteric
  • Viobin
  • Viokase
  • Zypanar

Systematic Name

  • Pancreatin

Superlist Name

  • Pancreatin

Mixture Names

  • Donnazyme
  • Entozyme
  • Stamyl

Registry Numbers

CAS Registry Number

  • 8049-47-6

Other Registry Numbers

  • 388123-90-8
  • 8057-43-0
  • 9002-16-8
  • 9046-39-3

System Generated Number

  • 0008049476

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2100mg/kg (2100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
mouse LD50 subcutaneous 3870mg/kg (3870mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
rat LD50 intraperitoneal 2550mg/kg (2550mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
rat LD50 oral > 10gm/kg (10000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 2427, 1975.