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Substance Name: Simethicone [USAN:USP]
RN: 8050-81-5

Note

  • A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added SILICA GEL. It is used as an antiflatulent, surfactant, and ointment base.

Molecular Formula

  • Unspecified

Molecular Weight

  • 238.4622
 

Classification Codes

  • Antiflatulent
  • Antifoaming Agents
  • Dermatologic Agents
  • Emollients
  • Surface-Active Agents

Names and Synonyms

Name of Substance

  • Silicone antifoam agent S 184
  • Silicone antifoam emulsions SE 6 and SE 9
  • Simethicone
  • Simethicone [USAN:USP]

MeSH Heading

  • Simethicone

Synonyms

  • alpha-(Trimethylsilyl)-omega-methylpoly(oxy(dimethylsilylene)), mixture with silicon dioxide
  • Antifoam A
  • Antifoam AF
  • DC antifoam A
  • Disflatyl
  • Gas-X
  • HSDB 3906
  • Mylanta Gas Relief
  • Mylicon Infant's Drops
  • Phazyme
  • Sab Simplex
  • Sentry Simethicone
  • Sentry Simethicone Emulsion
  • Simethicone
  • Simeticone

Systematic Name

  • Simethicone

Superlist Name

  • Simethicone

Mixture Names

  • Asidopan Plus
  • Di-Gel
  • Gelusil
  • Kudrox
  • Maalox HRF
  • Maalox Plus
  • Mylanta
  • Phazyme
  • Riopan Plus
  • Rioplus
  • Simeco
  • Wydrate Plus

Registry Numbers

CAS Registry Number

  • 8050-81-5

System Generated Number

  • 0008050815

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 900mg/kg (900mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
AMA Archives of Surgery. Vol. 78, Pg. 220, 1959.
dog LD50 parenteral 20mg/kg (20mg/kg) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES AMA Archives of Surgery. Vol. 78, Pg. 220, 1959.