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Substance Name: Cactinomycin [USAN:INN]
RN: 8052-16-2
UNII: 0OCC969V50
InChIKey: QCXJFISCRQIYID-IAEPZHFASA-N

Note

  • A mixture of dactinomycin, actinomycin C2, and actinomycin C3.

Molecular Formula

  • C62-H89-N11-O17

Molecular Weight

  • 1269.4562
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibiotics, Antineoplastic
  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Mutation Data
  • Natural Product
  • Protein Synthesis Inhibitors
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Cactinomycin
  • Cactinomycin [USAN:INN]

Synonyms

  • Actinochrysin
  • Cactinomicina
  • Cactinomicina [INN-Spanish]
  • Cactinomycin
  • Cactinomycine
  • Cactinomycine [INN-French]
  • Cactinomycinum
  • Cactinomycinum [INN-Latin]
  • EINECS 232-485-1
  • H.B.F. 386
  • HBF 386
  • Mixture of dactinomycin (10%), actinomycin C2 (45%), and actinomycin C3 (45%)
  • NSC 18268
  • NSC-18268
  • Sanamicia
  • Sanamycin
  • UNII-0OCC969V50

Systematic Names

  • Actinomycin C
  • Actinomycin D, 2(sup A)-D-alloisoleucine-2(sup B)-D-alloisoleucine-, mixt. with actinomycin D and 2(sup A)-D-alloisoleucineactinomycin D

Registry Numbers

CAS Registry Number

  • 8052-16-2

FDA UNII

  • 0OCC969V50

System Generated Number

  • 0008052162

Structure Descriptors

InChI

1S/C63H88N12O16/c1-17-31(8)44-61(86)75-25-19-21-38(75)59(84)71(14)27-40(77)73(16)50(30(6)7)63(88)90-35(12)46(57(82)67-44)69-55(80)41-42(64)51(78)33(10)53-48(41)65-47-36(23-22-32(9)52(47)91-53)54(79)68-45-34(11)89-62(87)49(29(4)5)72(15)39(76)26-70(13)58(83)37-20-18-24-74(37)60(85)43(28(2)3)66-56(45)81/h22-23,28-31,34-35,37-38,43-46,49-50H,17-21,24-27,64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)/t31-,34+,35+,37-,38-,43-,44-,45-,46-,49-,50-/m0/s1

InChIKey

QCXJFISCRQIYID-IAEPZHFASA-N

Smiles

CC[C@H](C)[C@H]1C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)c3c(c(=O)c(c-4oc5c(ccc(c5nc34)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@@H](NC6=O)C(C)C)C)C)C(C)C)C)C)C)N)C)C(C)C)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1110ug/kg (1.11mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 559, 1957.
mouse LD50 intravenous 1mg/kg (1mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(2), Pg. 53, 1980.
mouse LDLo oral 500mg/kg (500mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 14, Pg. 60, 1955.
rat LD50 intravenous 100mg/kg (100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
rat LD50 parenteral 100mg/kg (100mg/kg)   Recent Results in Cancer Research. Vol. 52, Pg. 76, 1975.