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Substance Name: Horse chestnut
RN: 8053-39-2

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • Unspecified
 

Names and Synonyms

MeSH Heading

  • Aesculus

Synonyms

  • Aesculus hippocastanum L. (Hippocastanaceae)
  • Buckeye
  • Chestnut, horse
  • EHS
  • EINECS 232-497-7
  • Horse chestnut
  • Horse chestnut pollen
  • Horse chestnut, Aesculus hippocastanum, ext.

Systematic Name

  • Horse chestnut, Aesculus hippocastanum, ext.

Mixture Name

  • Arthro ionx

Registry Numbers

CAS Registry Number

  • 8053-39-2

Other Registry Numbers

  • 84082-52-0
  • 84603-82-7

System Generated Number

  • 0008053392

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 37mg/kg (37mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
guinea pig LD50 intravenous 940mg/kg (940mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
guinea pig LD50 oral 1120mg/kg (1120mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
mouse LD50 intraperitoneal 6700ug/kg (6.7mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
mouse LD50 intraperitoneal 55mg/kg (55mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 45, 1980.
mouse LD50 intravenous 14400ug/kg (14.4mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
mouse LD50 intravenous 1377mg/kg (1377mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
mouse LD50 oral 164mg/kg (164mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
mouse LD50 oral 990mg/kg (990mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
mouse LD50 subcutaneous 38500ug/kg (38.5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rabbit LD50 intravenous 30mg/kg (30mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rabbit LD50 intravenous 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rabbit LD50 oral 1530mg/kg (1530mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
rat LD50 intraperitoneal 10100ug/kg (10.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
rat LD50 intraperitoneal 13750mg/kg (13750mg/kg)   Drugs in Japan Vol. 6, Pg. 399, 1982.
rat LD50 intravenous 62500ug/kg (62.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rat LD50 intravenous 1450mg/kg (1450mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
rat LD50 oral 833mg/kg (833mg/kg)   Yakkyoku. Pharmacy. Vol. 33, Pg. 335, 1982.
rat LD50 oral 2150mg/kg (2150mg/kg)   Drugs in Japan Vol. 6, Pg. 398, 1982.
rat LD50 subcutaneous 150mg/kg (150mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.