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Substance Name: Acetaminophen [USP:JAN]
RN: 103-90-2
UNII: 362O9ITL9D
InChIKey: RZVAJINKPMORJF-UHFFFAOYSA-N
Note
- Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
Molecular Formula
- C8-H9-N-O2
Molecular Weight
- 151.1641
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Non-Narcotic
- Antipyretic
- Antipyretics
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
- Tumor Data
Superlist Classification Code
- Overall Carcinogenic Evaluation: Group 3
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Regulatory Agencies (Superlist Locators)
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Names and Synonyms
Name of Substance
- Acetaminophen
- Acetaminophen [USP:JAN]
MeSH Heading
- Acetaminophen
Synonyms
- 222 AF
- 4'-Hydroxyacetanilide
- 4-(Acetylamino)phenol
- 4-13-00-01091 (Beilstein Handbook Reference)
- 4-Acetamidophenol
- 4-Hydroxyanilid kyseliny octove
- 4-Hydroxyanilid kyseliny octove [Czech]
- A-Per
- A.F. Anacin
- Abenol
- Abensanil
- Abrol
- Abrolet
- Acamol
- Acenol
- Acenol (pharmaceutical)
- Acephen
- Acertol
- Acetaco
- Acetagesic
- Acetalgin
- Acetamide, N-(p-hydroxyphenyl)-
- Acetaminofen
- Acetaminophen
- Acetamol
- Acetanilide, 4'-hydroxy-
- Acetofen
- Actron
- Afebrin
- Afebryl
- Aferadol
- Algesidal
- Algina
- Algomol
- Algotropyl
- Alpiny
- Alvedon
- Amadil
- Anacin-3
- Anadin dla dzieci
- Anaflon
- Analter
- Andox
- Anelix
- Anhiba
- Anti-Algos
- Antidol
- Apacet
- Apamide
- APAP
- Apitrelal
- Arfen
- Asetam
- Asomal
- Aspac
- Asplin
- Atasol
- Atralidon
- Babikan
- Bacetamol
- Banesin
- Ben-u-ron
- Benmyo
- Biocetamol
- Cadafen
- Calapol
- Calmanticold
- Calpol
- Capital with codeine
- Captin
- Causalon
- CCRIS 3
- Cefalex
- Children's Acetaminophen Elixir Drops
- Children's Acetaminophen Elixir Solution
- Children's Acetaminophen Oral Solution
- Children's Tylenol Chewable
- Claradol Codeine
- Clixodyne
- Cod-Acamol Forte
- Codabrol
- Codalgin
- Codapane
- Codicet
- Codisal
- Codisal Forte
- Codoliprane
- Codral Pain Relief
- Cofamol
- Contra-Schmerz P
- Cosutone
- Crocin
- Croix Blanche
- Cuponol
- Curadon
- Curpol
- Custodial
- Dafalgan
- Dafalgan Codeine
- Darocet
- Datril
- Daygrip
- Deminofen
- Democyl
- Demogripal
- Desfebre
- Dhamol
- Dial-a-gesic
- Dirox
- Disprol
- Dol-Stop
- Dolcor
- Dolefin
- Dolegrippin
- Dolgesic
- Doliprane
- Dolko
- Dolofugin
- Doloreduct
- Dolorfug
- Dolorol Forte
- Dolorstop
- Dolotec
- Dolprone
- Dorocoff
- Dresan
- Dristancito
- Duaneo
- Duorol
- Duracetamol
- Durapan
- Dymadon
- Dymadon Co
- Dymadon Forte
- EC 203-157-5
- Ecosetol
- EINECS 203-157-5
- Enelfa
- Eneril
- Eu-Med
- Excipain
- Exdol
- Fanalgic
- Farmadol
- Febranine
- Febrectal
- Febrectol
- Febrex
- Febricet
- Febridol
- Febrilix
- Febrin
- Febro-gesic
- Febrolin
- Fendon
- Fensum
- Fepanil
- Fever All
- Finimal
- Finiweh
- Flexsure
- Fluparmol
- Fortalidon P
- Freka-cetamol
- Gattaphen T
- Gelocatil
- Geluprane
- Geralgine-P
- Gripin Bebe
- Grippostad
- Gynospasmine
- Hedex
- Helon N
- Homoolan
- HSDB 3001
- Ildamol
- Inalgex
- Infadrops
- Infants' Feverall
- Influbene N
- Injectapap
- Junior Disprol
- Kataprin
- Kinder Finimal
- Kratofin simplex
- Labamol
- Lekadol
- Lemgrip
- Lemsip
- Lestemp
- Liquagesic
- Liquigesic Co
- Lonarid
- Lonarid Mono
- Lupocet
- Lyteca
- Magnidol
- Malex N
- Malgis
- Malidens
- Maxadol
- Medinol Paediatric
- Medocodene
- Melabon Infantil
- Mexalen
- Migraleve Yellow
- Minafen
- Minoset
- Miralgin
- Momentum
- Mono Praecimed
- Multin
- N-(4-Hydroxyphenyl)acetamide
- N-(4-Hydroxyphenyl)acetanilide
- N-Acetyl-p-aminophenol
- Naprinol
- NCI-C55801
- NCX 701
- NEBS
- Neo-Fepramol
- NeoCitran
- Neodol
- Neodolito
- Neopap
- Neuridon
- New Cortal for Children
- NilnOcen
- Nina
- No-Febril
- Nodolex
- Noral
- NSC 109028
- Ofirmev
- Oltyl
- Oralgan
- Ortensan
- Oxycocet
- p-Acetamidophenol
- p-Acetaminophenol
- p-Acetylaminophenol
- p-Hydroxyacetanilide
- Paceco
- Pacemo
- Pacemol
- Pacet
- Pacimol
- Paedialgon
- Paedol
- Paldesic
- Pamol
- Panacete
- Panadeine
- Panadeine Co
- Panadiene
- Panado-Co
- Panado-Co Caplets
- Panadol
- Panamax
- Panasorbe
- Panets
- Panodil
- Pantalgin
- Para-Suppo
- Para-Tabs
- Paracemol
- Paracenol
- Paracet
- Paracetamol
- Paracetamol AL
- Paracetamol Antipanin P
- Paracetamol Basics
- Paracetamol BC
- Paracetamol Dr. Schmidgall
- Paracetamol Fecofar
- Paracetamol Genericon
- Paracetamol Hanseler
- Paracetamol Harkley
- Paracetamol Heumann
- Paracetamol Hexal
- Paracetamol Italfarmaco
- Paracetamol Nycomed
- Paracetamol PB
- Paracetamol Raffo
- Paracetamol Ratiopharm
- Paracetamol Rosch
- Paracetamol Saar
- Paracetamol SmithKline Beecham
- Paracetamol Stada
- Paracetamol von ct
- Paracetamol Winthrop
- Paracetamol [INN:BAN]
- Paracetamolo
- Paracetamolo [Italian]
- Paracetamolum
- Paracetamolum [INN-Latin]
- Paracetol
- Paracin
- Paracod
- Paracodol
- Parador
- Paradrops
- Parakapton
- Parake
- Paralen
- Paralief
- Paralink
- Paralyoc
- Paramol
- Paramolan
- Paranox
- Parasedol
- Parasin
- Parcetol
- Parmol
- Parogal
- Paroma
- PCM Paracetamol Lichtenstein
- Pe-Tam
- Pediapirin
- Pediatrix
- Percocet-5
- Percocet-Demi
- Perdolan Mono
- Perfalgan
- Phenaphen
- Phenaphen W/Codeine
- Phenipirin
- Phogoglandin
- Pinex
- Piramin
- Pirinasol
- Plicet
- Polmofen
- Predimol
- Predualito
- Prodol
- Prontina
- Puernol
- Pulmofen
- Pyregesic-C
- Pyrigesic
- Pyrinazine
- Pyromed
- Reliv
- Remedol
- Resfenol
- Rockamol Plus
- Rounox
- RubieMol
- Rubophen
- Rupemol
- Salzone
- Sanicet
- Sanicopyrine
- Scanol
- Scentalgyl
- Scherzatabletten Rezeptur 534
- Schmerzex
- Sedalito
- Semolacin
- Servigesic
- Seskamol
- Setakop
- Setamol
- Setol
- Sifenol
- Sinaspril
- Sinedol
- Sinmol
- Spalt fur die nacht
- Spalt N
- St Joseph Aspirin-Free
- St Joseph Aspirin-Free for Children
- Stanback
- Stopain
- Sunetheton
- Supadol mono
- Supofen
- Suppap
- Supramol-M
- Tabalgin
- Tachiprina
- Tapar
- Tazamol
- Tempra
- Termacet
- Termalgin
- Termalgine
- Termofren
- Tiffy
- Titralgan
- Toximer P
- Tralgon
- Treupel mon
- Treupel N
- Treuphadol
- Tricoton
- Tussapap
- Tylenol
- Tylenol (caplet)
- Tylenol (geltab)
- Tylenol 8-Hour
- Tylex
- Tylex CD
- Tylol
- Tymol
- UNII-362O9ITL9D
- Upsanol
- Utragin
- Valadol
- Valgesic
- Veralgina
- Vermidon
- Verpol
- Viclor Richet
- Vips
- Viruflu
- Vivimed
- Volpan
- Zatinol
- Zolben
Systematic Names
- Acetamide, N-(4-hydroxyphenyl)-
- Acetaminophen
- Acetanilide, 4'-hydroxy-
- Paracetamol
Superlist Names
- Acetaminophen
- DEA No. 9804
- Paracetamol
- Tylenol
Mixture Names
- Actifed Plus
- Anexsia
- Aspirin-Free Anacin
- Bayer Select Allergy-Sinus
- Bayer Select Head Cold
- Bayer Select Headache Pain
- Bayer Select Menstrual Multi-Symptom
- Bayer Select Sinus Pain Relief
- Contac Cough & Sore Throat Formula
- Coricidin
- Coricidin D
- Coricidin Sinus
- Darvocet-N
- Demilets
- DHCplus
- Dristan Cold No Drowsiness
- Drixoral Cold & Flu
- Drixoral Sinus
- Empracet
- Endecon
- Hy-Phen
- Hycomine Compound
- Intensin
- Jin Gang
- Liquiprin
- Midol Maximum Strength
- Midol PM Night Time Formula
- Midol Regular Strength
- Midol Teen Formula
- Naldegesic
- Ornex Severe Cold Formula
- Percocet
- Percogesic with Codeine
- Propacet
- Quiet World
- Rhinex D-Lay Tablets
- Robitussin Night Relief
- Sine-Aid, Maximum Strength
- Sine-Off Sinus Medicine Caplets
- Sinubid
- St. Joseph Cold Tablets for Children
- Sudafed Cold and Cough
- Sudafed Severe Cold Formula
- Sudafed Sinus
- Supac
- Talacen
- TheraFlu
- Triaminic Sore Throat Formula
- Tylenol Allergy Sinus
- Tylox
- Vanquish
- Vicodin
Registry Numbers
CAS Registry Number
- 103-90-2
FDA UNII
- 362O9ITL9D
Other Registry Numbers
- 1430221-00-3
- 719293-04-6
- 8055-08-1
System Generated Number
- 0000103902
Structure Descriptors
InChI
1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)InChIKey
RZVAJINKPMORJF-UHFFFAOYSA-NSmiles
c1(ccc(cc1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | LDLo | oral | 50mg/kg (50mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA CARDIAC: OTHER CHANGES | American Journal of Emergency Medicine. Vol. 6, Pg. 510, 1988. |
| child | LDLo | oral | 140mg/kg/7D-I (140mg/kg) | BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" BEHAVIORAL: COMA LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" | Medical Journal of Australia. Vol. 171, Pg. 472, 1999. |
| child | LDLo | oral | 360mg/kg/2D (360mg/kg) | LIVER: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pediatrics. Vol. 92, Pg. 832, 1978. |
| child | TDLo | oral | 591mg/kg/2D-I (591mg/kg) | BLOOD: APLASTIC ANEMIA LIVER: LIVER FUNCTION TESTS IMPAIRED KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Clinical Pediatrics Vol. 33, Pg. 42, 1994. |
| child | TDLo | oral | 801mg/kg (801mg/kg) | LIVER: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: GENERAL ANESTHETIC | Pediatrics. Vol. 61, Pg. 68, 1978. |
| dog | LDLo | intravenous | 826mg/kg (826mg/kg) | BEHAVIORAL: ANALGESIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. |
| dog | LDLo | oral | 2gm/kg (2000mg/kg) | BLOOD: CHANGES IN SPLEEN BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 24, Pg. 602, 1993. |
| frog | LDLo | subcutaneous | 50mg/kg (50mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 33, Pg. 216, 1894. |
| guinea pig | LD50 | oral | 2620mg/kg (2620mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
| human | LDLo | oral | 143mg/kg (143mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | British Medical Journal. Vol. 282, Pg. 199, 1981. |
| human | LDLo | oral | 357mg/kg (357mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ANOREXIA (HUMAN BEHAVIORAL: COMA | Lancet. Vol. 1, Pg. 66, 1973. |
| infant | TDLo | oral | 1440mg/kg/6D (1440mg/kg) | American Journal of Diseases of Children. Vol. 137, Pg. 386, 1983. | |
| infant | TDLo | oral | 1440mg/kg/6D (1440mg/kg) | BEHAVIORAL: IRRITABILITY GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | American Journal of Diseases of Children. Vol. 137, Pg. 386, 1983. |
| mammal (species unspecified) | LD50 | unreported | 891mg/kg (891mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 22, 1983. | |
| mammal (species unspecified) | LDLo | oral | 512mg/kg (512mg/kg) | United States Patent Document. Vol. #4035499, | |
| man | LDLo | oral | 143mg/kg/24H- (143mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" | American Journal of Medicine. Vol. 74, Pg. 349, 1983. |
| man | LDLo | oral | 714mg/kg (714mg/kg) | LIVER: OTHER CHANGES | Human Toxicology. Vol. 1, Pg. 25, 1981. |
| man | TDLo | oral | 9286ug/kg (9.286mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SENSE ORGANS AND SPECIAL SENSES: OTHER: EAR | Allergy. Vol. 50(Suppl, |
| man | TDLo | oral | 714mg/kg (714mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | Postgraduate Medical Journal. Vol. 69, Pg. 52, 1993. |
| mouse | LD50 | intraperitoneal | 367mg/kg (367mg/kg) | BEHAVIORAL: ANALGESIA | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 520, 1965. |
| mouse | LD50 | oral | 338mg/kg (338mg/kg) | Toxicology and Applied Pharmacology. Vol. 19, Pg. 20, 1971. | |
| mouse | LD50 | subcutaneous | 310mg/kg (310mg/kg) | Human Toxicology. Vol. 3, Pg. 13S, 1984. | |
| pig | LDLo | intravenous | 1gm/kg (1000mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES | Veterinary and Human Toxicology. Vol. 30, Pg. 324, 1988. |
| rat | LD50 | intraperitoneal | 1205mg/kg (1205mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Studi Sassaresi, Sezione 2. Vol. 57, Pg. 561, 1979. |
| rat | LD50 | oral | 1944mg/kg (1944mg/kg) | United States Patent Document. Vol. #4636513, | |
| women | LDLo | oral | 260mg/kg (260mg/kg) | BEHAVIORAL: COMA GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | JAMA, Journal of the American Medical Association. Vol. 236, Pg. 1874, 1976. |
| women | LDLo | oral | 400mg/kg (400mg/kg) | BEHAVIORAL: COMA LIVER: LIVER FUNCTION TESTS IMPAIRED | Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 325, 1997. |
| women | LDLo | oral | 650mg/kg (650mg/kg) | American Journal of Emergency Medicine. Vol. 6, Pg. 511, 1988. | |
| women | LDLo | oral | 650mg/kg (650mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION VASCULAR: OTHER CHANGES | American Journal of Emergency Medicine. Vol. 6, Pg. 511, 1988. |
| women | TDLo | oral | 4962ug/kg (4.962mg/kg) | LIVER: LIVER FUNCTION TESTS IMPAIRED GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS BLOOD: OTHER CHANGES | Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 223, 1991. |
| women | TDLo | oral | 13mg/kg (13mg/kg) | BEHAVIORAL: EXCITEMENT | Allergy. Vol. 50(Suppl, |
| women | TDLo | oral | 325mg/kg (325mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Postgraduate Medical Journal. Vol. 68, Pg. 116, 1992. |
| women | TDLo | oral | 490mg/kg (490mg/kg) | GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Southern Medical Journal. Vol. 71, Pg. 906, 1978. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 170 | deg C | EXP | |
| pKa Dissociation Constant | 9.38 | (none) | EXP | |
| log P (octanol-water) | 0.46 | (none) | EXP | |
| Water Solubility | 1.40E+04 | mg/L | 25 | EXP |
| Vapor Pressure | 7.00E-06 | mm Hg | 25 | EST |
| Henry's Law Constant | 6.42E-13 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.77E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.