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Substance Name: Crataegus extract
RN: 8057-51-0

Note

  • Contains triterpene acids, anthocyanin type pigments, flavone derivatives, acetylcholine, choline, trimethylamine, chlorogenic acid; caffeic acid, ascorbic acid used as a cardiotonic & coronary vasodilator.

Molecular Formula

  • Unspecified
 

Classification Code

  • Natural Product
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Links to Resources

Names and Synonyms

Name of Substance

  • Crataegus extract

Synonym

  • Esbericard

Systematic Name

  • Crataegus, extract

Registry Numbers

CAS Registry Number

  • 8057-51-0

System Generated Number

  • 0008057510

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1200mg/kg (1200mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Planta Medica. Vol. 43, Pg. 105, 1981.
duck LDLo intravenous 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Planta Medica. Vol. 43, Pg. 105, 1981.
frog LDLo parenteral 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Planta Medica. Vol. 43, Pg. 105, 1981.
guinea pig LDLo intravenous 1500mg/kg (1500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Planta Medica. Vol. 43, Pg. 105, 1981.
mouse LD50 oral 18500mg/kg (18500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 68, 1969.
rabbit LDLo intravenous 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Planta Medica. Vol. 43, Pg. 105, 1981.
rat LD50 oral 33800mg/kg (33800mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 16, Pg. 68, 1969.
rat LDLo intravenous 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Planta Medica. Vol. 43, Pg. 105, 1981.