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Substance Name: Balsalazide [INN:BAN]
RN: 80573-04-2
UNII: P80AL8J7ZP
InChIKey: IPOKCKJONYRRHP-FMQUCBEESA-N

Note

  • A mesalamine 5-aminosalicylate prodrug; 99% of ingested drug remains intact through the stomach and is delivered to and activated in the colon; used for inflammatory bowel disease, ulcerative colitis and radiation-induced proctosigmoiditis but avoided in patients with known hypersensitivity reaction to salicylates or mesalamine.

Molecular Formula

  • C17-H15-N3-O6

Molecular Weight

  • 357.3205
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Peripheral Nervous System Agents
  • Sensory System Agents

Names and Synonyms

Results Name

  • Balsalazide [INN:BAN]

Name of Substance

  • Balsalazide [INN:BAN]

Synonyms

  • (E)-5-((4-(((2-Carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxybenzoic acid
  • Balsalazida
  • Balsalazida [Spanish]
  • Balsalazide
  • Balsalazido
  • Balsalazido [Spanish]
  • Balsalazidum
  • Balsalazidum [Latin]
  • UNII-P80AL8J7ZP

Systematic Name

  • Benzoic acid, 5-((4-(((2-carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxy-, (E)-

Registry Numbers

CAS Registry Number

  • 80573-04-2

FDA UNII

  • P80AL8J7ZP

System Generated Number

  • 0080573042

Structure Descriptors

InChI

1S/C17H15N3O6/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26)/b20-19+

InChIKey

IPOKCKJONYRRHP-FMQUCBEESA-N

Smiles

c1cc(ccc1C(=O)NCCC(=O)O)/N=N/c2ccc(c(c2)C(=O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 4gm/kg (4000mg/kg)   Drugs of the Future. Vol. 9, Pg. 313, 1984.
rat LD oral > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 9, Pg. 313, 1984.
women TDLo oral 1080mg/kg/8D- (1080mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PERICARDITIS

LIVER: "JAUNDICE, CHOLESTATIC"
British Medical Journal. Vol. 320, Pg. 613, 2000.