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Substance Name: Curare
RN: 8063-06-7

Note

  • Plant extracts from several species, including genera STRYCHNOS and Chondodendron, which contain TETRAHYDROISOQUINOLINES that produce PARALYSIS of skeletal muscle. These extracts are toxic and must be used with the administration of artificial respiration.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Human Data
  • Natural Product
  • Neuromuscular Agents
  • Neuromuscular Blocking Agents
  • Neuromuscular Nondepolarizing Agents
  • Neurotransmitter Agents
  • Nicotinic Antagonists
  • Peripheral Nervous System Agents

Names and Synonyms

Name of Substance

  • Curare

MeSH Heading

  • Curare

Synonyms

  • Curare
  • EINECS 232-511-1
  • Extractum toxiferum americanum
  • Intocostrin
  • Intocostrine
  • Ourari
  • Urari
  • Woorali
  • Woorari
  • Wourara

Systematic Name

  • Curare

Registry Numbers

CAS Registry Number

  • 8063-06-7

System Generated Number

  • 0008063067

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 1200ug/kg (1.2mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 266, 1944.
man LDLo unreported 735ug/kg (0.735mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intraperitoneal 3200ug/kg (3.2mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 308, 1965.
mouse LD50 intravenous 140ug/kg (0.14mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 118, Pg. 756, 1965.
mouse LD50 subcutaneous 500ug/kg (0.5mg/kg)   Naturwissenschaften. Vol. 56, Pg. 615, 1969.
rabbit LD50 intravenous 1300ug/kg (1.3mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 266, 1944.
rabbit LDLo oral 270mg/kg (270mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.
rabbit LDLo subcutaneous 2700ug/kg (2.7mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.