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Substance Name: Sulfamethoxazole mixture with trimethoprim
RN: 8064-90-2
InChIKey: WZRJTRPJURQBRM-UHFFFAOYSA-N

Note

  • A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.

Molecular Formula

  • C14-H18-N4-O3.C10-H11-N3-O3-S

Molecular Weight

  • 543.6021
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Anti-Infective Agents, Urinary
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Renal Agents

Names and Synonyms

Results Name

  • Sulfamethoxazole mixture with trimethoprim

Name of Substance

  • Trimethoprim-sulfamethoxazole combination
  • Trimethoprim/sulfamethoxazole

MeSH Heading

  • Trimethoprim, Sulfamethoxazole Drug Combination

Synonyms

  • A 033
  • Abacin
  • Abactrim
  • Acuco
  • Agoprim
  • Alfatrim
  • Aposulfatrim
  • Bacteral
  • Bacterial forte
  • Bactilen
  • Bactiver
  • Bacton
  • Bactoreduct
  • Bactramin
  • Bactrim
  • Bactrim DS
  • Bactrim Forte
  • Bactrim Pediatric
  • Bactrizol
  • Bactromin
  • Bactropin
  • Baktar
  • Baktrisid-DS
  • Berlocid
  • Bibacrim
  • Biseptol
  • Centrim
  • Chemitrim
  • Chemotrim
  • Ciplin
  • Co-trim-tablinen
  • Co-Trimaxazol
  • CO-Trimoxazole
  • Comox
  • Cotribene
  • Cotrim
  • Cotrim D.S.
  • Cotrim Eu Rho
  • Cotrim Holsen
  • Cotrim-Hefa
  • Cotrim-Puren
  • Cotrim-radiopharm
  • Cotrim.L.U.T.
  • Cotrimhexal
  • Cotrimox-Wolff
  • Cotrimoxazol
  • Cotrimoxazol AL
  • Cotrimoxazol-Cophar
  • Cotrimoxazole
  • Cotrimstada
  • Cotrim_BASF
  • Cotriver
  • Dibaprim
  • Diseptyl
  • Drylin
  • Duon
  • Duratrimet
  • Eltrianyl
  • Escoprim
  • Esteprim
  • Eusaprim
  • Fectrim
  • Gantaprim
  • Gantaprin
  • Gantrim
  • Groprim
  • Helveprim
  • HSDB 6780
  • Imexim
  • Jenamoxazol
  • Kemoprim
  • Kepinol
  • Kepinol Forte
  • Laratrim
  • Linaris
  • Maxtrim
  • Microtrim
  • Microtrim forte
  • Mikrosid
  • Momentol
  • Nopil
  • NSC 618652
  • Oecotrim
  • Omsat
  • Oriprim
  • Oxaprim
  • Pantoprim
  • Primazole
  • Septra
  • Septra DS
  • Septra Grape
  • Septrim
  • Servitrim
  • Sigaprim
  • Sigaprin
  • SMX / TMP
  • SMX-TMP
  • SMX/TMP
  • Strepto-Plus
  • Sulfa-Tyl
  • Sulfameth/TMP
  • Sulfameth/Trimeth
  • Sulfamethoprim
  • Sulfamethoprim-DS
  • Sulfamethoxazole / TMP
  • Sulfamethoxazole / trimethoprim
  • Sulfamethoxazole and trimethoprim
  • Sulfamethoxazole and Trimethoprim Double Strength
  • Sulfamethoxazole and Trimethoprim Single Strength
  • Sulfamethoxazole mixture with trimethoprim
  • Sulfamethoxazole trimethoprim
  • Sulfamethoxazole-trimeth
  • Sulfamethoxazole-trimethoprim
  • Sulfatrim
  • Sulfatrim pediatric
  • Sulfatrim-DS
  • Sulfatrim-SS
  • Sulfotrim
  • Sulfotrimin
  • Sulmeprim
  • Sulmeprim pediatric
  • Sulprim
  • Sumetrolim
  • Supracombin
  • Suprim
  • Tacumil
  • Teleprim
  • Teleprin
  • Thiocuran
  • TMP / SMX
  • Tmp-smx
  • TMP/SMX
  • TMS 480
  • Tribakin
  • Trifen
  • Trigonyl
  • Trimesulf
  • Trimeth/Sulfa
  • Trimetho comp
  • Trimethoprim and sulfamethoxazole
  • Trimethoprim and sulphamethoxazole
  • Trimethoprim-sulfamethoxazole
  • Trimethoprim-sulfamethoxazole combination
  • Trimethoprimsulfa
  • Trimetoger
  • Trimexazol
  • Trimexole-F
  • Trimforte
  • Trimosulfa
  • Uro-septra
  • Uroplus
  • Uroplus DS
  • Uroplus SS

Systematic Names

  • Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine
  • Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)- and N'-(5-methyl-3-isoxazolyl)sulfanilamide

Registry Numbers

CAS Registry Number

  • 8064-90-2

Other Registry Numbers

  • 117385-88-3
  • 37341-72-3
  • 38916-35-7
  • 50641-67-3
  • 50808-41-8
  • 52499-85-1
  • 74711-00-5
  • 8064-91-3
  • 8076-73-1

System Generated Number

  • 0008064902

Molecular Formulas

Molecular Formula

  • C14-H18-N4-O3.C10-H11-N3-O3-S

Molecular Formula Fragments

  • C10-H11-N3-O3-S
  • C14-H18-N4-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChIKey

WZRJTRPJURQBRM-UHFFFAOYSA-N

Smiles

Cc1cc(no1)NS(=O)(=O)c2ccc(cc2)N.COc1cc(cc(c1OC)OC)Cc2cnc(nc2N)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 432mg/kg/9D-I (432mg/kg) BLOOD: THROMBOCYTOPENIA Southern Medical Journal. Vol. 76, Pg. 503, 1983.
human LDLo oral 274mg/kg/10D- (274mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Lancet. Vol. 1, Pg. 831, 1978.
man TDLo intravenous 80mg/kg/4D-I (80mg/kg)   Annals of Internal Medicine. Vol. 103, Pg. 161, 1985.
man TDLo oral 457mg/kg/5D-I (457mg/kg) ENDOCRINE: HYPOGLYCEMIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
New York State Journal of Medicine. Vol. 84, Pg. 30, 1984.
man TDLo unreported 576mg/kg/1W-I (576mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS Annals of Internal Medicine. Vol. 104, Pg. 363, 1986.
mouse LD50 intraperitoneal 2010mg/kg (2010mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Chemotherapy Vol. 21, Pg. 175, 1973.
mouse LD50 oral 3740mg/kg (3740mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 2716, 1978.
mouse LD50 subcutaneous > 3gm/kg (3000mg/kg)   Chemotherapy Vol. 21, Pg. 175, 1973.
rat LD50 intraperitoneal 1840mg/kg (1840mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Chemotherapy Vol. 21, Pg. 175, 1973.
rat LD50 oral 5350mg/kg (5350mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 2716, 1978.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg)   Chemotherapy Vol. 21, Pg. 175, 1973.
women TDLo oral 19mg/kg (19mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Annals of Internal Medicine. Vol. 106, Pg. 331, 1987.
women TDLo oral 22400ug/kg/7D (22.4mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

LIVER: "JAUNDICE, CHOLESTATIC"
Postgraduate Medical Journal. Vol. 56, Pg. 202, 1980.