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Substance Name: Levothyroxine Sodium mixture with Liothyronine Sodium
RN: 8065-29-0
UNII: YW8HJ0N26X
InChIKey: LKYWLLWWYBVUPP-XOCLESOZSA-L

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Thyroid Hormone

Molecular Formula

  • C15-H12-I3-N-O4.C15-H11-I4-N-O4.2Na

Molecular Weight

  • 1471.78
 
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Names and Synonyms

Results Name

  • Levothyroxine Sodium mixture with Liothyronine Sodium

Name of Substance

  • Levothyroxine Sodium mixture with Liothyronine Sodium
  • Liotrix [USAN:USP]

Synonyms

  • Combithyrex
  • Diotroxin
  • Euthroid
  • L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt, hydrate, mixt. with O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine monosodium salt
  • Levothyroxine mixture with Liothyronine
  • Levothyroxine Sodium mixture with Liothyronine Sodium
  • Liothyronine Sodium and Levothyroxine Sodium
  • Liotrix
  • Monosodium L-thyroxine hydrate mixt. with monosodium L-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine
  • Novothyral
  • Thyrolar
  • UNII-YW8HJ0N26X
  • W 1782

Systematic Name

  • L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt, mixt. with O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine monosodium salt

Registry Numbers

CAS Registry Number

  • 8065-29-0

FDA UNII

  • YW8HJ0N26X

Related Registry Number

  • 8061-58-3 (Parent)

System Generated Number

  • 0008065290

Molecular Formulas

Molecular Formula

  • C15-H12-I3-N-O4.C15-H11-I4-N-O4.2Na

Molecular Formula Fragments

  • C15-H11-I4-N-O4
  • C15-H12-I3-N-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C15H11I4NO4.C15H12I3NO4.2Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);1-4,6,12,20H,5,19H2,(H,21,22);;/q;;2*+1/p-2/t2*12-;;/m00../s1

InChIKey

LKYWLLWWYBVUPP-XOCLESOZSA-L

Smiles

C([O-])(=O)[C@H](Cc1cc(c(c(I)c1)Oc1ccc(O)c(I)c1)I)N.[Na+].c1(c(c(cc(c1)Oc1c(cc(cc1I)C[C@@H](C(=O)[O-])N)I)I)O)I.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 200ug/kg/13W- (0.2mg/kg) BEHAVIORAL: HEADACHE

BEHAVIORAL: MUSCLE WEAKNESS
American Journal of Diseases of Children. Vol. 138, Pg. 927, 1984.