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Substance Name: Ergoloid mesylates [USAN:USP]
RN: 8067-24-1
UNII: X3S33EX3KW

Note

  • A mixture of the mesylates (methane sulfonates) of DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and the alpha- and beta-isomers of DIHYDROERGOCRYPTINE. The substance produces a generalized peripheral vasodilation and a fall in arterial pressure and has been used to treat symptoms of mild to moderate impairment of mental function in the elderly.

Molecular Formula

  • C31-H41-N5-O5.C-H4-O3-S

Molecular Weight

  • 616.712
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Cognition Adjuvant
  • Drug / Therapeutic Agent
  • Mutation Data
  • Neurotransmitter Agents
  • Nootropic Agents
  • Reproductive Effect
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Ergoloid mesylates
  • Ergoloid mesylates [USAN:USP]

MeSH Heading

  • Ergoloid mesylates

Synonyms

  • Alkergot
  • An equiproportional mixture of dihydroergocornine mesylate, dihydroergocristine mesylate, and ratio of dihydro-alpha-ergocryptine mesylate to dihydro-beta-ergocryptine mesylate is 1.5-2.5:1
  • CCK 179
  • Circanol
  • CO-Dergocrine mesylate
  • Codergocrine mesilate
  • Deapril
  • Deapril-ST
  • Dihydroergotoxin mesylate
  • Dihydroergotoxin methanesulfonate
  • Dihydroergotoxine mesilate
  • Dihydroergotoxine mesylate
  • Dihydroergotoxine methanesulfonate
  • Dihydroergotoxine methanesulphonate
  • Dihydroergotoxine monomethanesulfonate (salt)
  • Ergoloid mesylates
  • Gerimal
  • Hydergin
  • Hydergine
  • Hydergine LC
  • Hydrogenated Ergot Alkaloids
  • Ischelium
  • Redergin
  • Trigot
  • UNII-X3S33EX3KW

Systematic Names

  • Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2',5'-bis(1-methylethyl)-, (5'alpha,10alpha)-, monomethanesulfonate (salt) mixture with 9,10alpha-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione monomethanesulfonate (salt), 9,10alpha-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'alpha-(2-methylpropyl)ergotaman-3',6',18-trione monomethanesulfonate (salt), and 9,10alpha-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'alpha-(1-methylpropyl)ergotaman-3',6',18-trione monomethanesulfonate (salt)
  • Ergotoxine, dihydro-, methanesulfonate
  • Ergotoxine, dihydro-, monomethanesulfonate (salt) (9CI)

Registry Numbers

CAS Registry Number

  • 8067-24-1

FDA UNII

  • X3S33EX3KW

Other Registry Numbers

  • 11006-63-6
  • 12645-43-1
  • 42615-51-0
  • 52655-92-2
  • 8031-73-0

System Generated Number

  • 0008067241

Molecular Formulas

Molecular Formula

  • C31-H41-N5-O5.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C31-H41-N5-O5
  • COMPONENT

Structure Descriptors

Smiles

N12[C@@]([C@H]3N(CCC3)C([C@@H]2*)=O)(O[C@](NC([C@@H]2C[C@@H]3c4c5c(c[nH]c5ccc4)C[C@H]3[N@@](C2)C)=O)(C(C)C)C1=O)O.CS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 350mg/kg (350mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.
mouse LD50 intravenous 180mg/kg (180mg/kg)   Drugs in Japan Vol. 6, Pg. 329, 1982.
mouse LD50 oral > 1mg/kg (1mg/kg)   Drugs in Japan Vol. 6, Pg. 329, 1982.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.
rabbit LD50 intravenous > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.
rabbit LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.
rat LD50 intraperitoneal 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.
rat LD50 intravenous 86mg/kg (86mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.
rat LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 469, 1990.