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Substance Name: Alfaxalone mixture with alfadolone acetate
RN: 8067-82-1
InChIKey: YYPNLXNMXQFMHG-GSEHKNNPSA-N

Note

  • A 3:1 mixture of alfaxalone with alfadolone acetate that previously had been used as a general anesthetic. It is no longer actively marketed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1445)

Molecular Formula

  • C23-H34-O5.C21-H32-O3

Molecular Weight

  • 722.997
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Alfaxalone mixture with alfadolone acetate

Name of Substance

  • Alfaxalone mixture with alfadolone acetate
  • Althesin

MeSH Heading

  • Alfaxalone alfadolone mixture

Synonyms

  • Alfadione
  • Alfatesine
  • Alfatesine [French]
  • Alfathesin
  • Alphadione
  • Althesin
  • Aurantex
  • CT-1341
  • Saffan

Systematic Names

  • 5-alpha-Pregnane-11,20-dione, 3-alpha-hydroxy- mixed with 3-alpha,21-dihydroxy-5-alpha-pregnane-11,20-dione 21-acetate (3:1)
  • Pregnane-11,20-dione, 21-(acetyloxy)-3-hydroxy-, (3alpha,5alpha)-, mixt. with (3alpha,5alpha)-3-hydroxypregnane-11,20-dione

Registry Numbers

CAS Registry Number

  • 8067-82-1

System Generated Number

  • 0008067821

Molecular Formulas

Molecular Formula

  • C23-H34-O5.C21-H32-O3

Molecular Formula Fragments

  • C21-H32-O3
  • C23-H34-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C23H34O5.C21H32O3/c1-13(24)28-12-20(27)18-7-6-17-16-5-4-14-10-15(25)8-9-22(14,2)21(16)19(26)11-23(17,18)3;1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h14-18,21,25H,4-12H2,1-3H3;13-17,19,23H,4-11H2,1-3H3/t14-,15+,16-,17-,18+,21+,22-,23-;13-,14+,15-,16+,17-,19+,20-,21+/m00/s1

InChIKey

YYPNLXNMXQFMHG-GSEHKNNPSA-N

Smiles

C1[C@H]2[C@H]3[C@@]([C@H](CC3)C(COC(C)=O)=O)(CC([C@@H]2[C@@]2([C@@H](C[C@H](O)CC2)C1)C)=O)C.C1[C@@H]2[C@@H]([C@@]3([C@@H](C[C@H](O)CC3)C1)C)C(C[C@@]1([C@H]2CC[C@@H]1C(C)=O)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 140mg/kg (140mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of the Egyptian Medical Association. Vol. 62, Pg. 191, 1979.
mouse LD50 intravenous 47mg/kg (47mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of the Egyptian Medical Association. Vol. 62, Pg. 191, 1979.
rabbit LD50 intravenous 12700ug/kg (12.7mg/kg)   Proceedings of the European Society of Toxicology. Vol. 16, Pg. 208, 1975.
rat LD50 intraperitoneal 79mg/kg (79mg/kg)   Therapie. Vol. 32, Pg. 375, 1977.
rat LD50 intravenous 36mg/kg (36mg/kg)   Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 1, Pg. 119, 1975.
women LDLo intravenous 125mg/kg (125mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Practitioner. Vol. 222, Pg. 249, 1979.