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Substance Name: Rentiapril [INN]
RN: 80830-42-8
UNII: D0TAM1017B
InChIKey: BSHDUMDXSRLRBI-JOYOIKCWSA-N

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Protease Inhibitors
  • Reproductive Effect

Molecular Formula

  • C13-H15-N-O4-S2

Molecular Weight

  • 313.397
 
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Names and Synonyms

Name of Substance

  • Rentiapril [INN]

Synonyms

  • (2R,4R)-2-(o-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid
  • BRN 5762860
  • CCRIS 2341
  • Fentiapril
  • Prescrin
  • Rentiapril
  • Rentiaprilum
  • Rentiaprilum [Latin]
  • SA 446
  • UNII-D0TAM1017B

Systematic Names

  • (2R,4R)-2-(o-Hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid
  • 4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-, (2R-cis)-
  • SA 466

Registry Numbers

CAS Registry Number

  • 80830-42-8

FDA UNII

  • D0TAM1017B

System Generated Number

  • 0080830428

Structure Descriptors

InChI

1S/C13H15NO4S2/c15-10-4-2-1-3-8(10)12-14(11(16)5-6-19)9(7-20-12)13(17)18/h1-4,9,12,15,19H,5-7H2,(H,17,18)/t9-,12+/m0/s1

InChIKey

BSHDUMDXSRLRBI-JOYOIKCWSA-N

Smiles

C(CS)C(=O)N1[C@@H](c2c(cccc2)O)SC[C@H]1C(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
mouse LD50 intravenous 946mg/kg (946mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
mouse LD50 oral 8050mg/kg (8050mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
mouse LD50 subcutaneous 2213mg/kg (2213mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
rat LD50 intraperitoneal 921mg/kg (921mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
rat LD50 intravenous 884mg/kg (884mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
rat LD50 oral 8290mg/kg (8290mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.
rat LD50 subcutaneous 1369mg/kg (1369mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 235, 1986.