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Substance Name: Indolapril [INN]
RN: 80876-01-3
UNII: R07Y89H0HB
InChIKey: VXFJYXUZANRPDJ-MQBSTWLZSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H34-N2-O5

Molecular Weight

  • 430.5416
 
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Names and Synonyms

Results Name

  • Indolapril [INN]

Name of Substance

  • Indolapril
  • Indolapril [INN]

Synonyms

  • (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarobxylic acid 1-ethyl ester
  • (2S,3aS,7aS)-1-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-2-hexahydroindolinecarbonsaeure
  • Indolapril
  • Indolaprilum
  • Indolaprilum [Latin]
  • Sch 31846
  • UNII-R07Y89H0HB

Systematic Name

  • 1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-beta,7a-beta))-

Registry Numbers

CAS Registry Number

  • 80876-01-3

FDA UNII

  • R07Y89H0HB

System Generated Number

  • 0080876013

Structure Descriptors

InChI

1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18-,19-,20-,21-/m0/s1

InChIKey

VXFJYXUZANRPDJ-MQBSTWLZSA-N

Smiles

CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@H]3C[C@H]2C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 450mg/kg (450mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
New Cardiovascular Drugs. Vol. 3, Pg. 43, 1985.
mouse LD50 oral 1800mg/kg (1800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
New Cardiovascular Drugs. Vol. 3, Pg. 43, 1985.
rat LD50 intravenous 150mg/kg (150mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
New Cardiovascular Drugs. Vol. 3, Pg. 43, 1985.
rat LD50 oral 2500mg/kg (2500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
New Cardiovascular Drugs. Vol. 3, Pg. 43, 1985.