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Substance Name: Clarithromycin [USAN:USP:INN:BAN:JAN]
RN: 81103-11-9
UNII: H1250JIK0A
InChIKey: AGOYDEPGAOXOCK-KCBOHYOISA-N
Note
- A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit protein synthesis in bacteria by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Molecular Formula
- C38-H69-N-O13
Molecular Weight
- 747.9571
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial
- Antiviral (COVID-19)
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Metabolic Side Effects of Drugs and Substances
- Protein Synthesis Inhibitors
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Links to Resources
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Clarithromycin
- Clarithromycin [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Clarithromycin
Synonyms
- 6-O-Methylerythromycin
- 6-O-Methylerythromycin A
- A-56268
- Abbotic
- Abbott-56268
- Adel
- Astromen
- Biaxin
- Biaxin filmtab
- Biaxin HP
- Biaxin XL
- Biaxin xl filmtab
- Bicrolid
- CCRIS 8833
- Clacine
- Clambiotic
- Claribid
- Claricide
- Clarith
- Clarithromycin
- Clarithromycin extended release
- Clarithromycine
- Clarithromycine [INN-French]
- Clarithromycinum
- Clarithromycinum [INN-Latin]
- Claritromicina
- Claritromicina [INN-Spanish]
- Clathromycin
- Cyllid
- DRG-0099
- Helas
- Heliclar
- HSDB 8055
- Klacid
- Klaciped
- Klaricid
- Klaricid H.P.
- Klaricid Pediatric
- Klarid
- Klarin
- Klax
- Kofron
- Mabicrol
- Macladin
- Maclar
- Mavid
- Naxy
- TE-031
- UNII-H1250JIK0A
- Veclam
- Zeclar
Systematic Name
- Erythromycin, 6-O-methyl-
Superlist Name
- Clarithromycin
Registry Numbers
CAS Registry Number
- 81103-11-9
FDA UNII
- H1250JIK0A
System Generated Number
- 0081103119
Structure Descriptors
InChI
InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1InChIKey
AGOYDEPGAOXOCK-KCBOHYOISA-NSmiles
CC[C@H]1OC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD | oral | > 5gm/kg (5000mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1453, 1988. |
mouse | LD50 | intraperitoneal | 850mg/kg (850mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Chemotherapy Vol. 36(Suppl, |
mouse | LD50 | intravenous | 173mg/kg (173mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 769, 1991. | |
mouse | LD50 | oral | 1230mg/kg (1230mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1433, 1988. |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE | Chemotherapy Vol. 36(Suppl, |
rat | LD50 | intraperitoneal | 669mg/kg (669mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Chemotherapy Vol. 36(Suppl, |
rat | LD50 | oral | 1270mg/kg (1270mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 1433, 1988. |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE | Chemotherapy Vol. 36(Suppl, |
women | TDLo | oral | 30mg/kg/3D-I (30mg/kg) | CARDIAC: CHANGE IN RATE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Annals of Emergency Medicine. Vol. 30, Pg. 542, 1997. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 220 dec | deg C | EXP | |
pKa Dissociation Constant | 8.99 | (none) | 25 | EXP |
log P (octanol-water) | 3.16 | (none) | EXP | |
Water Solubility | 0.342 | mg/L | 25 | EST |
Vapor Pressure | 8.60E-27 | mm Hg | 25 | EST |
Henry's Law Constant | 1.73E-29 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 4.78E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.