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Substance Name: Esmolol hydrochloride [USAN]
RN: 81161-17-3
UNII: V05260LC8D
InChIKey: GEKNCWBANDDJJL-UHFFFAOYSA-N

Classification Codes

  • Anti-Adrenergic (beta-Receptor)
  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C16-H25-N-O4.Cl-H

Molecular Weight

  • 331.8374
 
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Names and Synonyms

Name of Substance

  • ASL 8052
  • Esmolol hydrochloride
  • Esmolol hydrochloride [USAN]

Synonyms

  • (+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate hydrochloride
  • 4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoic acid methyl ester HCl
  • ASL 8052
  • ASL-8052
  • Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride, (+-)-
  • Brevibloc
  • Brevibloc Double Strength in plastic container
  • Brevibloc in plastic container
  • Esmolol HCl
  • Esmolol hydrochloride
  • HSDB 6530
  • UNII-V05260LC8D

Systematic Names

  • Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride
  • Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride, (+-)-

Registry Numbers

CAS Registry Number

  • 81161-17-3

FDA UNII

  • V05260LC8D

Related Registry Number

  • 81147-92-4 (Parent)

System Generated Number

  • 0081161173

Molecular Formulas

Molecular Formula

  • C16-H25-N-O4.Cl-H

Molecular Formula Fragments

  • C16-H25-N-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H

InChIKey

GEKNCWBANDDJJL-UHFFFAOYSA-N

Smiles

c1(ccc(cc1)CCC(=O)OC)OCC(CNC(C)C)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 32mg/kg (32mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
New Cardiovascular Drugs. Vol. 3, Pg. 99, 1985.
man TDLo intravenous 775ug/kg/14M- (0.775mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 484, 1988.
mouse LD50 intravenous 93mg/kg (93mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 99, 1985.
rabbit LD50 intravenous 40mg/kg (40mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 99, 1985.
rat LD50 intravenous 71mg/kg (71mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 99, 1985.