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Substance Name: Alfuzosin hydrochloride [USAN:USP]
RN: 81403-68-1
UNII: 75046A1XTN
InChIKey: YTNKWDJILNVLGX-UHFFFAOYSA-N

Classification Code

  • Antihypertensive (alpha-Blocker)

Molecular Formula

  • C19-H27-N5-O4.Cl-H

Molecular Weight

  • 425.9142
 

Names and Synonyms

Name of Substance

  • Alfuzosin hydrochloride [USAN:USP]

Synonyms

  • (+-)-N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furamide monohydrochloride
  • 2-Furancarboxamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-, monohydrochloride (+-)-
  • Alfoten
  • Alfuzosin HCl
  • Alfuzosin hydrochloride
  • SL 77 499-10
  • SL 77499-10
  • SL77.0499-10
  • UNII-75046A1XTN
  • Urion
  • Uroxatral
  • Xatral

Systematic Name

  • 2-Furancarboxamide, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-, monohydrochloride (+-)-

Registry Numbers

CAS Registry Number

  • 81403-68-1

FDA UNII

  • 75046A1XTN

Other Registry Number

  • 133880-44-1

Related Registry Number

  • 81403-80-7 (Parent)

System Generated Number

  • 0081403681

Molecular Formulas

Molecular Formula

  • C19-H27-N5-O4.Cl-H

Molecular Formula Fragments

  • C19-H27-N5-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H

InChIKey

YTNKWDJILNVLGX-UHFFFAOYSA-N

Smiles

Cl.COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 200mg/kg (200mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 2569, 2000.
mouse LD50 intravenous 235mg/kg (235mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 2569, 2000.
rat LD50 intravenous 146mg/kg (146mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 2569, 2000.