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Substance Name: Cabergoline [USAN:USP:INN:BAN]
RN: 81409-90-7
UNII: LL60K9J05T
InChIKey: KORNTPPJEAJQIU-KJXAQDMKSA-N
Note
- An ergoline derivative and dopamine D2-agonist that inhibits PROLACTIN secretion. It is used in the management of HYPERPROLACTINEMIA, and to suppress lactation following childbirth for medical reasons. Cabergoline is also used in the management of PARKINSON DISEASE.
Molecular Formula
- C26-H37-N5-O2
Molecular Weight
- 451.611
Classification Codes
- Anti-Dyskinesia Agents
- Antidyskinetic
- Antihyperprolactinemic
- Antineoplastic Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Agonist
- Dopamine Agonists
- Drug / Therapeutic Agent
- Neurotransmitter Agents
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Names and Synonyms
Name of Substance
- Cabergoline
- Cabergoline [USAN:USP:INN:BAN]
MeSH Heading
- Cabergoline
Synonyms
- 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
- BRN 6020775
- Cabergolina
- Cabergolina [Spanish]
- Cabergoline
- Cabergolinum
- Cabergolinum [Latin]
- Dostinex
- Ergoline-8beta-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-
- FCE 21336
- UNII-LL60K9J05T
Systematic Names
- 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
- Ergoline-8-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-, (8-beta)-
Registry Numbers
CAS Registry Number
- 81409-90-7
FDA UNII
- LL60K9J05T
Related Registry Number
- 85329-89-1 (diphosphate)
System Generated Number
- 0081409907
Structure Descriptors
InChI
InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1InChIKey
KORNTPPJEAJQIU-KJXAQDMKSA-NSmiles
CCNC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | oral | > 400mg/kg (400mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 421, 1989. |