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Substance Name: Cabergoline [USAN:USP:INN:BAN]
RN: 81409-90-7
UNII: LL60K9J05T
InChIKey: KORNTPPJEAJQIU-KJXAQDMKSA-N

Note

  • Also acts as prolactin antagonist.

Molecular Formula

  • C26-H37-N5-O2

Molecular Weight

  • 451.611
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Antidyskinetic
  • Antihyperprolactinemic
  • Antineoplastic Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Dopamine Agents
  • Dopamine Agonist
  • Dopamine Agonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Cabergoline
  • Cabergoline [USAN:USP:INN:BAN]

MeSH Heading

  • Cabergoline

Synonyms

  • 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
  • BRN 6020775
  • Cabergolina
  • Cabergolina [Spanish]
  • Cabergoline
  • Cabergolinum
  • Cabergolinum [Latin]
  • Dostinex
  • Ergoline-8beta-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-
  • FCE 21336
  • UNII-LL60K9J05T

Systematic Names

  • 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
  • Ergoline-8-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-, (8-beta)-

Registry Numbers

CAS Registry Number

  • 81409-90-7

FDA UNII

  • LL60K9J05T

Related Registry Number

  • 85329-89-1 (diphosphate)

System Generated Number

  • 0081409907

Structure Descriptors

InChI

InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1

InChIKey

KORNTPPJEAJQIU-KJXAQDMKSA-N

Smiles

CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(CC=C)C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 400mg/kg (400mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 421, 1989.