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Substance Name: Cabergoline [USAN:USP:INN:BAN]
RN: 81409-90-7
UNII: LL60K9J05T
InChIKey: KORNTPPJEAJQIU-KJXAQDMKSA-N

Note

  • An ergoline derivative and dopamine D2-agonist that inhibits PROLACTIN secretion. It is used in the management of HYPERPROLACTINEMIA, and to suppress lactation following childbirth for medical reasons. Cabergoline is also used in the management of PARKINSON DISEASE.

Molecular Formula

  • C26-H37-N5-O2

Molecular Weight

  • 451.611
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Antidyskinetic
  • Antihyperprolactinemic
  • Antineoplastic Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Dopamine Agents
  • Dopamine Agonist
  • Dopamine Agonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Cabergoline
  • Cabergoline [USAN:USP:INN:BAN]

MeSH Heading

  • Cabergoline

Synonyms

  • 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
  • BRN 6020775
  • Cabergolina
  • Cabergolina [Spanish]
  • Cabergoline
  • Cabergolinum
  • Cabergolinum [Latin]
  • Dostinex
  • Ergoline-8beta-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-
  • FCE 21336
  • UNII-LL60K9J05T

Systematic Names

  • 1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
  • Ergoline-8-carboxamide, N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-6-(2-propenyl)-, (8-beta)-

Registry Numbers

CAS Registry Number

  • 81409-90-7

FDA UNII

  • LL60K9J05T

Related Registry Number

  • 85329-89-1 (diphosphate)

System Generated Number

  • 0081409907

Structure Descriptors

InChI

InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1

InChIKey

KORNTPPJEAJQIU-KJXAQDMKSA-N

Smiles

CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(CC=C)C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 400mg/kg (400mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 24, Pg. 421, 1989.