Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Nipradilol [INN:JAN]
RN: 81486-22-8
UNII: FVM336I71Y
InChIKey: OMCPLEZZPVJJIS-UHFFFAOYSA-N

Molecular Formula

  • C15-H22-N2-O6

Molecular Weight

  • 326.347
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
  • Reproductive Effect
  • Vasodilator Agents
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Nipradilol
  • Nipradilol [INN:JAN]

Synonyms

  • 3,4-Dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2H-1-benzopyran-3-ol 3-nitrate
  • 3,4-Dihydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-2H-1-benzopyran-3-ol 3-nitrate
  • 3,4-Dihydro-8-(2-hydroxy-3-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran
  • 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol 3-nitrate
  • 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate
  • 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanyl nitrat
  • BRN 3566879
  • CCRIS 2515
  • Hypadil
  • K 351
  • Nipradilol
  • Nipradilolum
  • Nipradilolum [Latin]
  • Nipradolol
  • UNII-FVM336I71Y

Systematic Names

  • 2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrate
  • 8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate
  • Nipradilol

Registry Numbers

CAS Registry Number

  • 81486-22-8

FDA UNII

  • FVM336I71Y

System Generated Number

  • 0081486228

Structure Descriptors

InChI

1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3

InChIKey

OMCPLEZZPVJJIS-UHFFFAOYSA-N

Smiles

O(C[C@@H](O)CNC(C)C)c1c2c(ccc1)C[C@@H](CO2)O[N+]([O-])=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 20mg/kg (20mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
dog LD50 oral > 400mg/kg (400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse LD50 intraperitoneal 147mg/kg (147mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse LD50 intravenous 68mg/kg (68mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse LD50 oral 461mg/kg (461mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
mouse LD50 subcutaneous 416mg/kg (416mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rabbit LD50 intravenous 20mg/kg (20mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989.
rabbit LD50 oral 300mg/kg (300mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat LD50 intraperitoneal 144mg/kg (144mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat LD50 intravenous 78mg/kg (78mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat LD50 oral 1040mg/kg (1040mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.
rat LD50 subcutaneous 850mg/kg (850mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 725, 1985.