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Substance Name: Nafamostat [INN]
RN: 81525-10-2
UNII: Y25LQ0H97D
InChIKey: MQQNFDZXWVTQEH-UHFFFAOYSA-N

Note

  • Inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic.

Molecular Formula

  • C19-H17-N5-O2

Molecular Weight

  • 347.3763
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticoagulants
  • Antirheumatic Agents
  • Complement Inactivating Agents
  • Enzyme Inhibitors
  • Hematologic Agents
  • Immunologic Factors
  • Immunosuppressive Agents
  • Peripheral Nervous System Agents
  • Protease Inhibitors
  • Sensory System Agents
  • Serine Proteinase Inhibitors
  • Trypsin Inhibitors
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Names and Synonyms

Name of Substance

  • Nafamostat
  • Nafamostat [INN]

Synonyms

  • 6-(Aminoiminomethyl)-2-naphthalenyl 4-((aminoiminomethyl)amino)benzoate
  • 6-Amidino2-naphthyl 4-guanidinobenzoate
  • Nafamostat
  • Nafamostatum
  • Nafamostatum [Latin]
  • p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidine
  • UNII-Y25LQ0H97D

Systematic Name

  • Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester

Registry Numbers

CAS Registry Number

  • 81525-10-2

FDA UNII

  • Y25LQ0H97D

System Generated Number

  • 0081525102

Structure Descriptors

InChI

1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)

InChIKey

MQQNFDZXWVTQEH-UHFFFAOYSA-N

Smiles

c1cc(ccc1C(=O)Oc2ccc3cc(ccc3c2)C(=N)N)NC(=N)N