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Substance Name: Trichlormethine hydrochloride
RN: 817-09-4
UNII: 00238AP6R9
InChIKey: VEAUDLLZYJVHRI-UHFFFAOYSA-N

Molecular Formula

  • C6-H12-Cl3-N.Cl-H

Molecular Weight

  • 240.9877
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms

Results Name

  • Trichlormethine hydrochloride

Name of Substance

  • 2,2',2''-Trichlorotriethylamine hydrochloride

Synonyms

  • 2,2',2''-Trichlorotriethylamine hydrochloride
  • 2-Chloro-N,N-bis(2-chloroethyl)ethanammonium chloride
  • AI3-16199
  • EINECS 212-442-3
  • Hn3 hcl
  • HN3 hydrochloride
  • Lekamin
  • NSC 260424
  • NSC-30211
  • R 47
  • R-47
  • Sinalost
  • SK-100
  • Tri(beta-chloroethyl)amine hydrochloride
  • Tri-(2-chloroethyl)amine hydrochloride
  • Trichlor-triaethylamin-hydrochlorid
  • Trichlor-triaethylamin-hydrochlorid [German]
  • Trichlormethin
  • Trichlormethine
  • Trichlormethinium chloride
  • Trichlorotriethylamine hydrochloride
  • Trillekamin
  • Trimitan
  • Trimustine
  • Trimustine hydrochloride
  • Tris(2-chloroethyl)amine hydrochloride
  • Tris(2-chloroethyl)amine monohydrochloride
  • Tris(2-chloroethyl)ammonium chloride
  • Tris(beta-chloroethyl)amine hydrochloride
  • Tris-N-lost
  • Tris-N-lost [German]
  • TS 160
  • UNII-00238AP6R9

Systematic Names

  • Ethanamine, 2-chloro-N,N-bis(2-chloroethyl)-, hydrochloride
  • Ethanamine, 2-chloro-N,N-bis(2-chloroethyl)-, hydrochloride (9CI)
  • Triethylamine, 2,2',2''-trichloro-, hydrochloride
  • Tris(2-chloroethyl)amine hydrochloride

Superlist Names

  • Trichlormethine
  • Trimustine hydrochloride

Registry Numbers

CAS Registry Number

  • 817-09-4

FDA UNII

  • 00238AP6R9

Related Registry Number

  • 555-77-1 (Parent)

System Generated Number

  • 0000817094

Molecular Formulas

Molecular Formula

  • C6-H12-Cl3-N.Cl-H

Molecular Formula Fragments

  • C6-H12-Cl3-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C6H12Cl3N.ClH/c7-1-4-10(5-2-8)6-3-9;/h1-6H2;1H

InChIKey

VEAUDLLZYJVHRI-UHFFFAOYSA-N

Smiles

C(CCl)N(CCCl)CCCl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD75 intravenous 1mg/kg (1mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 277, 1947.
human TDLo intravenous 100ug/kg (0.1mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE

BEHAVIORAL: HEADACHE
National Technical Information Service. Vol. PB158-507,
human TDLo oral 30ug/kg (0.03mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
National Technical Information Service. Vol. PB158-507,
human TDLo oral 214ug/kg (0.214mg/kg) BLOOD: LEUKOPENIA National Technical Information Service. Vol. PB158-507,
mouse LD50 intraperitoneal 1600ug/kg (1.6mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 559, 1957.
mouse LD50 oral 1100ug/kg (1.1mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 595, 1959.
mouse LD50 subcutaneous 2mg/kg (2mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947.
rabbit LD50 intravenous 2500ug/kg (2.5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 224, 1947.
rabbit LDLo oral 2mg/kg (2mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS British Journal of Pharmacology and Chemotherapy. Vol. 1, Pg. 247, 1946.
rat LD50 intraperitoneal 750ug/kg (0.75mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 8, Pg. 807, 1960.
rat LD50 intravenous 700ug/kg (0.7mg/kg)   National Technical Information Service. Vol. PB158-507,
rat LD50 subcutaneous 2mg/kg (2mg/kg)   National Technical Information Service. Vol. PB158-507,
rat LDLo oral 5mg/kg (5mg/kg)   National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 19, 1953.