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Substance Name: 1-Phthalidyl-5-fluorouracil
RN: 81820-68-0
UNII: NF1JN84R8K
InChIKey: JADGCGSQDUSAED-UHFFFAOYSA-N

Note

  • Prodrug of 5-fluorouracil.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C12-H7-F-N2-O4

Molecular Weight

  • 262.1953
 
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Names and Synonyms

Name of Substance

  • 1-Phthalidyl-5-fluorouracil

Synonyms

  • 1-(1,3-Dihydro-3-oxo-1-isobenzofuranyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione
  • 1-PFu
  • N(sub 1)-Phthalidyl-5-fluorouracil
  • UNII-NF1JN84R8K

Systematic Name

  • 2,4(1H,3H)-Pyrimidinedione, 1-(1,3-dihydro-3-oxo-1-isobenzofuranyl)-5-fluoro-

Registry Numbers

CAS Registry Number

  • 81820-68-0

FDA UNII

  • NF1JN84R8K

System Generated Number

  • 0081820680

Structure Descriptors

InChI

1S/C12H7FN2O4/c13-8-5-15(12(18)14-9(8)16)10-6-3-1-2-4-7(6)11(17)19-10/h1-5,10H,(H,14,16,18)

InChIKey

JADGCGSQDUSAED-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)C(OC2=O)n3cc(c(=O)[nH]c3=O)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 2500mg/kg (2500mg/kg)   Journal of Medicinal Chemistry. Vol. 25, Pg. 1219, 1982.