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Substance Name: Vesnarinone [USAN:INN:JAN]
RN: 81840-15-5
UNII: 5COW40EV8M
InChIKey: ZVNYJIZDIRKMBF-UHFFFAOYSA-N

Molecular Formula

  • C22-H25-N3-O4

Molecular Weight

  • 395.457
 

Classification Codes

  • Adjuvants, Immunologic
  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antiviral Agents
  • Cardiotonic
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Immunologic Factors
  • Phosphodiesterase Inhibitors
  • Protective Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Vesnarinone
  • Vesnarinone [USAN:INN:JAN]

Synonyms

  • 1-(1,2,3,4-Tetrahydro-2-oxo-6-quinolyl)-4-veratroylpiperazine
  • 1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
  • 3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone
  • 6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-
  • 6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-quinolone
  • Arkin
  • Arkin-Z
  • BRN 5644229
  • CCRIS 1451
  • DRG-0210
  • OPC-8212
  • Piteranometozine
  • UNII-5COW40EV8M
  • Vesnarinona
  • Vesnarinona [Spanish]
  • Vesnarinone
  • Vesnarinonum
  • Vesnarinonum [Latin]

Systematic Names

  • Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-
  • Vesnarinone

Registry Numbers

CAS Registry Number

  • 81840-15-5

FDA UNII

  • 5COW40EV8M

System Generated Number

  • 0081840155

Structure Descriptors

InChI

1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)

InChIKey

ZVNYJIZDIRKMBF-UHFFFAOYSA-N

Smiles

c1(N2CCN(C(c3cc(c(OC)cc3)OC)=O)CC2)cc2c(NC(=O)CC2)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 63300ug/kg (63.3mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
dog LD50 oral > 3gm/kg (3000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
mouse LD50 intraperitoneal > 1200mg/kg (1200mg/kg) LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
mouse LD50 intravenous 56300ug/kg (56.3mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
mouse LD50 oral > 7594mg/kg (7594mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
mouse LD50 oral > 7594mg/kg (7594mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
mouse LD50 subcutaneous > 1200mg/kg (1200mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
rabbit LD50 oral > 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
rat LD50 intraperitoneal > 1200mg/kg (1200mg/kg) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
rat LD50 intravenous 79300ug/kg (79.3mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
rat LD50 oral > 7594mg/kg (7594mg/kg) LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
women TDLo oral 16800ug/kg/14 (16.8mg/kg) BLOOD: AGRANULOCYTOSIS American Journal of Hematology. Vol. 44, Pg. 217, 1993.