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Substance Name: Cyclizine [USP:INN:BAN:DCF]
RN: 82-92-8
UNII: QRW9FCR9P2
InChIKey: UVKZSORBKUEBAZ-UHFFFAOYSA-N
Note
- A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Molecular Formula
- C18-H22-N2
Molecular Weight
- 266.3858
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antiemetics
- Antihistaminic
- Autonomic Agents
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Human Data
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Cyclizine
- Cyclizine [USP:INN:BAN:DCF]
MeSH Heading
- Cyclizine
Synonyms
- (+-)-1-Diphenylmethyl-4-methylpiperazine
- (N-Benzhydryl)(N'-methyl)diethylenediamine
- 1-(Diphenylmethyl)-4-methylpiperazine
- 1-Benzhydryl-4-methylpiperazin
- 5-23-01-00232 (Beilstein Handbook Reference)
- BRN 0230441
- BW 47-83
- Ciclizina
- Ciclizina [INN-Spanish]
- Compound 47-83
- Cyclizine
- Cyclizinum
- Cyclizinum [INN-Latin]
- EINECS 201-445-5
- HSDB 3309
- Marezine
- N-Benzhydryl-N'-methylpiperazine
- N-Methyl-N'-benzhydrylpiperazine
- Nautazine
- Neo-devomit
- NSC 26608
- UNII-QRW9FCR9P2
- Valoid
- Wellcome preparation 47-83
- Wellcome prepn 47-83
Systematic Names
- Cyclizine
- Piperazine, 1-(diphenylmethyl)-4-methyl-
Registry Numbers
CAS Registry Number
- 82-92-8
FDA UNII
- QRW9FCR9P2
System Generated Number
- 0000082928
Structure Descriptors
InChI
InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3InChIKey
UVKZSORBKUEBAZ-UHFFFAOYSA-NSmiles
CN1CCN(CC1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 147mg/kg (147mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 218, 1972. | |
| women | TDLo | oral | 126mg/kg/6W-I (126mg/kg) | BLOOD: AGRANULOCYTOSIS | British Medical Journal. Vol. 292, Pg. 174, 1986. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 105.5 | deg C | EXP | |
| log P (octanol-water) | 2.970 | (none) | EST | |
| Water Solubility | 1000 | mg/L | 25 | EXP |
| Atmospheric OH Rate Constant | 2.03E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.