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Substance Name: Epalrestat [INN]
RN: 82159-09-9
UNII: 424DV0807X
InChIKey: CHNUOJQWGUIOLD-NFZZJPOKSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme Inhibitors

Molecular Formula

  • C15-H13-N-O3-S2

Molecular Weight

  • 319.404
 
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Names and Synonyms

Name of Substance

  • Epalrestat
  • Epalrestat [INN]

Synonyms

  • 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
  • 5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
  • Epalrestat
  • Epalrestatum
  • Epalrestatum [Latin]
  • ONO 2235
  • Sorbistat
  • UNII-424DV0807X

Systematic Names

  • 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
  • 5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid

Registry Numbers

CAS Registry Number

  • 82159-09-9

FDA UNII

  • 424DV0807X

System Generated Number

  • 0082159099

Structure Descriptors

InChI

InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-

InChIKey

CHNUOJQWGUIOLD-NFZZJPOKSA-N

Smiles

C\C(=C/c1ccccc1)\C=C\2/SC(=S)N(CC(=O)O)C2=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse LD50 intraperitoneal 687mg/kg (687mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse LD50 intravenous 255ug/kg (0.255mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse LD50 oral 3200mg/kg (3200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
mouse LD50 subcutaneous > 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 intraperitoneal 922gm/kg (922000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 intravenous 255ug/kg (0.255mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 oral 5300ug/kg (5.3mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 201, 1992.