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Substance Name: Flufylline [INN]
RN: 82190-91-8
UNII: O8G173034U
InChIKey: PMEYQPKJAPXGPS-UHFFFAOYSA-N

Note

  • Has blood pressure lowering, serotonin & histamine antagonistic & broncholytic activity.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H24-F-N5-O3

Molecular Weight

  • 413.4506
 
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Names and Synonyms

Name of Substance

  • Flufylline
  • Flufylline [INN]

Synonyms

  • 1H-Purine-2,6-dione, 7-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-3,7-dihydro-1,3-dimethyl-
  • 7-(2-(4-(p-Fluorobenzoyl)piperidino)ethyl)theophylline
  • Flufilina
  • Flufilina [Spanish]
  • Flufyllin
  • Flufylline
  • Flufyllinum
  • Flufyllinum [Latin]
  • Sgd 195 78
  • UNII-O8G173034U

Systematic Names

  • 7-(2-(4-(p-Fluorobenzoyl)piperidino)ethyl)theophylline
  • Theophylline, 7-(2-(4-(p-fluorobenzoyl)piperidino)ethyl)-

Registry Numbers

CAS Registry Number

  • 82190-91-8

FDA UNII

  • O8G173034U

System Generated Number

  • 0082190918

Structure Descriptors

InChI

1S/C21H24FN5O3/c1-24-19-17(20(29)25(2)21(24)30)27(13-23-19)12-11-26-9-7-15(8-10-26)18(28)14-3-5-16(22)6-4-14/h3-6,13,15H,7-12H2,1-2H3

InChIKey

PMEYQPKJAPXGPS-UHFFFAOYSA-N

Smiles

Cn1c2c(c(=O)n(c1=O)C)n(cn2)CCN3CCC(CC3)C(=O)c4ccc(cc4)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 12mg/kg (12mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1, 1984.
mouse LD50 oral 149mg/kg (149mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 1, 1984.