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Substance Name: Ganciclovir [USAN:USP:INN:BAN:JAN]
RN: 82410-32-0
UNII: P9G3CKZ4P5
InChIKey: IRSCQMHQWWYFCW-UHFFFAOYSA-N
Note
- An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Molecular Formula
- C9-H13-N5-O4
Molecular Weight
- 255.2327
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Infective Agents
- Antiviral
- Antiviral Agents
- Drug / Therapeutic Agent
- Mutation Data
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Names and Synonyms
Name of Substance
- Ganciclovir
- Ganciclovir [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Ganciclovir
Synonyms
- 2'-NDG
- 2'-Nor-2'-deoxyguanosine
- 2-Amino-1,9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6-H-purin-6-one
- 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-
- 9-((1,3-Dihydroxy-2-propoxy)methyl)guanine
- 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine
- Biolf 62
- BW 759
- BW 759U
- BW-759U
- BW-B 759U
- CCRIS 9212
- Cytovene
- DHPG
- DRG-0018
- EC 627-054-3
- Ganciclovir
- Ganciclovirum
- Ganciclovirum [Latin]
- Gancyclovir
- Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-
- HHEMG
- HSDB 6512
- Hydroxyacyclovir
- NSC 759656
- RS-21592
- UNII-P9G3CKZ4P5
- Vitrasert
- Zirgan
Systematic Names
- 2-Amino-9-(((1,3-dihydroxypropan-2-yl)oxy)methyl)-6,9-dihydro-1H-purin-6-one
- 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-
- Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-
Registry Numbers
CAS Registry Number
- 82410-32-0
FDA UNII
- P9G3CKZ4P5
Other Registry Numbers
- 106931-35-5
- 86357-12-2
- 96551-29-0
Related Registry Number
- 107910-75-8 (mono-hydrochloride salt)
System Generated Number
- 0082410320
Structure Descriptors
InChI
InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)InChIKey
IRSCQMHQWWYFCW-UHFFFAOYSA-NSmiles
NC1=Nc2c(ncn2COC(CO)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | > 150mg/kg (150mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. | |
| dog | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. | |
| mouse | LD50 | intraperitoneal | 1gm/kg (1000mg/kg) | Journal of Medicinal Chemistry. Vol. 26, Pg. 759, 1983. | |
| mouse | LD50 | intravenous | 900mg/kg (900mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. | |
| mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. -, Pg. 291, 1990. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 250 dec | deg C | EXP | |
| log P (octanol-water) | -1.66E+00 | (none) | EXP | |
| Water Solubility | 4300 | mg/L | 25 | EXP |
| Vapor Pressure | 2.86E-17 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.54E-23 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 9.44E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.