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Substance Name: Moexipril hydrochloride [USAN]
RN: 82586-52-5
UNII: Q1UMG3UH45
InChIKey: JXRAXHBVZQZSIC-JKVLGAQCSA-N

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Enzyme Inhibitor (Angiotensin-Converting)

Molecular Formula

  • C27-H34-N2-O7.Cl-H

Molecular Weight

  • 535.0335
 
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Names and Synonyms

Name of Substance

  • Moexipril hydrochloride [USAN]

Synonyms

  • (3S)-2-((2S)-N-((1S)-1-Carboxy-3-phenylpropyl)alanyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, 2-ethyl ester, monohydrochloride
  • 3-Isoquinolinecarboxylic acid, 2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-, monohydrochloride, (3S-(2(R*(R*)),3R*))-
  • CI 925
  • Moexipril HCl
  • Moexipril hydrochloride
  • RS 10085-197
  • RS-10085-197
  • SPM 925
  • UNII-Q1UMG3UH45
  • Univasc

Systematic Names

  • 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, monohydrochloride, (3S-(2(R*(R*)),3R*))-
  • 3-Isoquinolinecarboxylic acid, 2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-, monohydrochloride, (3S-(2(R*(R*)),3R*))-

Registry Numbers

CAS Registry Number

  • 82586-52-5

FDA UNII

  • Q1UMG3UH45

System Generated Number

  • 0082586525

Molecular Formulas

Molecular Formula

  • C27-H34-N2-O7.Cl-H

Molecular Formula Fragments

  • C27-H34-N2-O7
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1

InChIKey

JXRAXHBVZQZSIC-JKVLGAQCSA-N

Smiles

CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3cc(c(cc3C[C@H]2C(=O)O)OC)OC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 900mg/kg (900mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 132, 1997.
mouse LD50 intravenous 830mg/kg (830mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 132, 1997.
mouse LD50 oral 2209mg/kg (2209mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 132, 1997.
rat LD50 intravenous 461mg/kg (461mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 132, 1997.
rat LD50 oral 4015mg/kg (4015mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 132, 1997.