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Substance Name: Quinapril hydrochloride [USAN:USP]
RN: 82586-55-8
UNII: 33067B3N2M
InChIKey: IBBLRJGOOANPTQ-JKVLGAQCSA-N

Molecular Formula

  • C25-H30-N2-O5.Cl-H

Molecular Weight

  • 474.982
 

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitor (Angiotensin-Converting)
  • Enzyme Inhibitors
  • Protease Inhibitors
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Quinapril hydrochloride
  • Quinapril hydrochloride [USAN:USP]

Synonyms

  • (S)-2-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, 1-ethyl ester, monohydrochloride
  • 3-Isoquinolinecarboxylic acid, 2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-, monohydrochloride, (3S-(2(R*(R*)),3R*))
  • Accupril
  • Accuprin
  • Accupron
  • Acequin
  • Acuitel
  • Acuprel
  • Asig
  • CI-906
  • CI906
  • Conan
  • Continucor
  • Ectren
  • Hemokvin
  • HSDB 7046
  • Korec
  • Koretic
  • Lidaltrin
  • PD 109452-2
  • Quinapril
  • Quinapril HCl
  • Quinapril hydrochloride
  • Quinazil
  • UNII-33067B3N2M

Systematic Names

  • 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, monohydrochloride, (3S-(2(R*(R*)),3R*))-
  • 3-Isoquinolinecarboxylic acid, 2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-, monohydrochloride, (3S-(2(R*(R*)),3R*))

Mixture Name

  • Accuretic

Registry Numbers

CAS Registry Number

  • 82586-55-8

FDA UNII

  • 33067B3N2M

System Generated Number

  • 0082586558

Molecular Formulas

Molecular Formula

  • C25-H30-N2-O5.Cl-H

Molecular Formula Fragments

  • C25-H30-N2-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1

InChIKey

IBBLRJGOOANPTQ-JKVLGAQCSA-N

Smiles

N1([C@@H](Cc2ccccc2C1)C(O)=O)C([C@@H](N[C@@H](CCc1ccccc1)C(OCC)=O)C)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 500mg/kg (500mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
mouse LD50 intravenous 504mg/kg (504mg/kg)   Angiology. Vol. 40, Pg. 335, 1989.
mouse LD50 oral 1739mg/kg (1739mg/kg)   Angiology. Vol. 40, Pg. 335, 1989.
rat LD50 intravenous 107mg/kg (107mg/kg)   Angiology. Vol. 40, Pg. 335, 1989.
rat LD50 oral 3541mg/kg (3541mg/kg)   Angiology. Vol. 40, Pg. 335, 1989.