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Substance Name: Raloxifene hydrochloride [USAN:USP]
RN: 82640-04-8
UNII: 4F86W47BR6
InChIKey: BKXVVCILCIUCLG-UHFFFAOYSA-N

Notes

  • A second generation selective estrogen receptor modulator ( SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
  • A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.

Molecular Formula

  • C28-H27-N-O4-S.Cl-H

Molecular Weight

  • 510.0512
 

Classification Codes

  • Anti-Estrogen
  • Bone Density Conservation Agents
  • Estrogen Antagonists
  • Estrogen Receptor Modulators
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Reproductive Effect
  • Selective Estrogen Receptor Modulators

Names and Synonyms

Name of Substance

  • Raloxifene hydrochloride [USAN:USP]

MeSH Heading

  • Raloxifene Hydrochloride

Synonyms

  • 6-Hydroxy-2-(p-hydroxyphenyl)benzo(b)thien-3-yl-p-(2-piperidinoethoxy)phenyl ketone, hydrochloride
  • Evista
  • Keoxifene hydrochloride
  • LY 156758
  • LY156758
  • Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-, hydrochloride
  • Raloxifene HCl
  • Raloxifene hydrochloride
  • UNII-4F86W47BR6

Systematic Name

  • Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 82640-04-8

FDA UNII

  • 4F86W47BR6

Related Registry Number

  • 84449-90-1 (Parent)

System Generated Number

  • 0082640048

Molecular Formulas

Molecular Formula

  • C28-H27-N-O4-S.Cl-H

Molecular Formula Fragments

  • C28-H27-N-O4-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H

InChIKey

BKXVVCILCIUCLG-UHFFFAOYSA-N

Smiles

c1cc(ccc1c2c(c3ccc(cc3s2)O)C(=O)c4ccc(cc4)OCCN5CCCCC5)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 36mg/kg/30D-I (36mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"

LIVER: LIVER FUNCTION TESTS IMPAIRED
Lancet. Vol. 352, Pg. 1524, 1998.