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Substance Name: Aceclidine [USAN:INN]
RN: 827-61-2
UNII: 0578K3ELIO
InChIKey: WRJPSSPFHGNBMG-UHFFFAOYSA-N

Note

  • Cholinomimetic used to reduce intraocular pressure in glaucoma.

Molecular Formula

  • C9-H15-N-O2

Molecular Weight

  • 169.2225
 

Classification Codes

  • Autonomic Agents
  • Cholinergic
  • Drug / Therapeutic Agent
  • Miotics
  • Parasympathomimetics
  • Peripheral Nervous System Agents
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Names and Synonyms

Name of Substance

  • Aceclidine
  • Aceclidine [USAN:INN]

Synonyms

  • 1-Azabicyclo(2.2.2)octan-3-ol, acetate
  • 1-Azabicyclo(2.2.2)octan-3-ol, acetate (ester)
  • 3-Acetoxyquinuclidine
  • 3-Quinuclidinol acetate
  • 3-Quinuclidinol acetate (ester)
  • Aceclidina
  • Aceclidina [INN-Spanish]
  • Aceclidine
  • Aceclidinum
  • Aceclidinum [INN-Latin]
  • AL 304
  • EINECS 212-574-1
  • Glaucostat
  • NSC 657843
  • UNII-0578K3ELIO

Systematic Names

  • 1-Azabicyclo(2.2.2)octan-3-ol, acetate (ester)
  • 3-Quinuclidinol, acetate (ester)
  • Aceclidine

Registry Numbers

CAS Registry Number

  • 827-61-2

FDA UNII

  • 0578K3ELIO

Other Registry Number

  • 72353-53-8

System Generated Number

  • 0000827612

Structure Descriptors

InChI

1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3

InChIKey

WRJPSSPFHGNBMG-UHFFFAOYSA-N

Smiles

CC(=O)OC1CN2CCC1CC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 78mg/kg (78mg/kg) BEHAVIORAL: ANALGESIA

BEHAVIORAL: TREMOR
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 189, Pg. 295, 1971.
mouse LD50 intravenous 36mg/kg (36mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Russian Pharmacology and Toxicology Vol. 35, Pg. 55, 1972.
mouse LD50 oral 165mg/kg (165mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 320, 1968.
mouse LD50 subcutaneous 102mg/kg (102mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 320, 1968.
rat LD50 intravenous 45mg/kg (45mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 320, 1968.
rat LD50 subcutaneous 225mg/kg (225mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 320, 1968.