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Substance Name: Perindopril [USAN:INN:BAN]
RN: 82834-16-0
UNII: Y5GMK36KGY
InChIKey: IPVQLZZIHOAWMC-QXKUPLGCSA-N

Note

  • An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.

Molecular Formula

  • C19-H32-N2-O5

Molecular Weight

  • 368.4708
 

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitor (Angiotensin-Converting)
  • Enzyme Inhibitors
  • Human Data
  • Protease Inhibitors
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Perindopril
  • Perindopril [USAN:INN:BAN]

MeSH Heading

  • Perindopril

Synonyms

  • (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
  • 1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-
  • BRN 4300272
  • Coversyl
  • McN-A 2833
  • McN-A-2833
  • Perindopril
  • Perindoprilum
  • Perindoprilum [Latin]
  • S 9490
  • S-9490
  • UNII-Y5GMK36KGY

Systematic Names

  • 11H-Indole-2-carboxylic acid, octahydro-1-(2-((1-ethoxycarbonyl)butyl)amino)-1-oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-beta,7a-beta))-
  • 1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-

Registry Numbers

CAS Registry Number

  • 82834-16-0

FDA UNII

  • Y5GMK36KGY

Other Registry Number

  • 99149-83-4

System Generated Number

  • 0082834160

Structure Descriptors

InChI

1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1

InChIKey

IPVQLZZIHOAWMC-QXKUPLGCSA-N

Smiles

CCC[C@H](N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O)C(=O)OCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1600mg/kg (1600mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
monkey LD50 oral > 500mg/kg (500mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1679, 1994.
mouse LD50 intravenous 679mg/kg (679mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
mouse LD50 oral > 2500mg/kg (2500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1673, 1994.
rat LD50 intravenous 323mg/kg (323mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
rat LD50 oral > 3gm/kg (3000mg/kg)   Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
women TDLo oral 58mg/kg/2Y-I (58mg/kg) BLOOD: AGRANULOCYTOSIS Annales de Medecine Interne. Vol. 147, Pg. 523, 1996.