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Substance Name: Combretastatin
RN: 82855-09-2
UNII: 7O62J06F18
InChIKey: LGZKGOGODCLQHG-CYBMUJFWSA-N

Note

  • Cytotoxic principle from South African tree COMBRETUM caffrum; acts at COLCHICINE site of TUBULIN.

Molecular Formula

  • C18-H22-O6

Molecular Weight

  • 334.3658
 

Classification Codes

  • Antimitotic Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Mitosis Modulators
  • Tubulin Modulators
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Names and Synonyms

Name of Substance

  • Combretastatin

Synonyms

  • (-)-Combretastatin
  • (R)-(-)-Combretastatin
  • 3-Hydroxy-4-methoxy-alpha-(3,4,5-trimethoxyphenyl)benzeneethanol
  • Combretastatin
  • NSC 348103
  • UNII-7O62J06F18

Systematic Names

  • Benzeneethanol, 3-hydroxy-4-methoxy-alpha-(3,4,5-trimethoxyphenyl)-, (alphaR)-
  • Benzeneethanol, 3-hydroxy-4-methoxy-alpha-(3,4,5-trimethoxyphenyl)-, (R)-

Registry Numbers

CAS Registry Number

  • 82855-09-2

FDA UNII

  • 7O62J06F18

System Generated Number

  • 0082855092

Structure Descriptors

InChI

1S/C18H22O6/c1-21-15-6-5-11(8-14(15)20)7-13(19)12-9-16(22-2)18(24-4)17(10-12)23-3/h5-6,8-10,13,19-20H,7H2,1-4H3/t13-/m1/s1

InChIKey

LGZKGOGODCLQHG-CYBMUJFWSA-N

Smiles

COc1ccc(C[C@@H](O)c2cc(OC)c(OC)c(OC)c2)cc1O