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Substance Name: Nafamostat mesylate [USAN]
RN: 82956-11-4
UNII: 1D2T74921W
InChIKey: SRXKIZXIRHMPFW-UHFFFAOYSA-N

Note

  • Inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic

Molecular Formula

  • C19-H17-N5-O2.2C-H4-O3-S

Molecular Weight

  • 539.588
 

Classification Codes

  • Anticoagulant
  • Antifibrinolytic
  • Antifibrinolytic Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Nafamostat dimethanesulfonate
  • Nafamostat mesylate [USAN]

Synonyms

  • 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate
  • 6-Amidino-2-naphthyl p-guanidinobenzoate, dimethanesulfonate
  • Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate
  • FUT 175
  • FUT-175
  • Nafamostat mesilate
  • Nafamostat mesylate
  • UNII-1D2T74921W

Systematic Name

  • Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate

Registry Numbers

CAS Registry Number

  • 82956-11-4

FDA UNII

  • 1D2T74921W

System Generated Number

  • 0082956114

Molecular Formulas

Molecular Formula

  • C19-H17-N5-O2.2C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C19-H17-N5-O2
  • COMPONENT

Structure Descriptors

InChI

1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)

InChIKey

SRXKIZXIRHMPFW-UHFFFAOYSA-N

Smiles

c12c(cc(cc2)OC(c2ccc(NC(=N)[NH2+])cc2)=O)ccc(c1)C(=N)[NH2+].S(C)(=O)(=O)[O-].S(C)(=O)(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 intraperitoneal 200mg/kg (200mg/kg)   United States Patent Document. Vol. #4454338,
mammal (species unspecified) LD50 oral 2500mg/kg (2500mg/kg)   United States Patent Document. Vol. #4454338,
mouse LD50 intraperitoneal 269mg/kg (269mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 intravenous 24400ug/kg (24.4mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 oral 4600mg/kg (4600mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
mouse LD50 subcutaneous 6180mg/kg (6180mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 intraperitoneal 162mg/kg (162mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 intravenous 16400ug/kg (16.4mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 oral 3050mg/kg (3050mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.
rat LD50 subcutaneous 9200mg/kg (9200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 1106, 1986.