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Substance Name: Methylprednisolone [USP:INN:BAN:JAN]
RN: 83-43-2
UNII: X4W7ZR7023
InChIKey: VHRSUDSXCMQTMA-PJHHCJLFSA-N
Note
- A PREDNISOLONE derivative with similar anti-inflammatory action.
Molecular Formula
- C22-H30-O5
Molecular Weight
- 374.474
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Antiemetics
- Antiviral (COVID-19)
- Autonomic Agents
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Glucocorticoid
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Human Data
- Immunosuppressant
- Neuroprotective Agents
- Peripheral Nervous System Agents
- Protective Agents
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Names and Synonyms
Name of Substance
- Methylprednisolone
- Methylprednisolone [USP:INN:BAN:JAN]
MeSH Heading
- Methylprednisolone
Synonyms
- 1-Dehydro-6alpha-methylhydrocortisone
- 11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
- 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
- 11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
- 4-08-00-03498 (Beilstein Handbook Reference)
- 6-alpha-Methylprednisolone
- 6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
- 6alpha-Methylprednisolone
- A-Methapred
- Artisone-wyeth
- Besonia
- BRN 2340300
- delta(1)-6alpha-Methylhydrocortisone
- delta(sup 1)-6-alpha-Methylhydrocortisone
- Depo-Medrol (acetate)
- Dopomedrol
- EC 201-476-4
- EINECS 201-476-4
- Esametone
- Firmacort
- HSDB 3127
- Lemod
- Medesone
- Medixon
- Medlone 21
- Medrate
- Medrol
- Medrol adt pak
- Medrol dosepak
- Medrone
- Mesopren
- Metastab
- Methyleneprednisolone
- Methylprednisolone
- Methylprednisolonum
- Methylprednisolonum [INN-Latin]
- Metilbetasone
- Metilprednisolona
- Metilprednisolona [INN-Spanish]
- Metilprednisolone
- Metilprednisolone [DCIT]
- Metrisone
- Metrocort
- Metysolon
- Moderin
- Nirypan
- Noretona
- NSC-19987
- Predni N Tablinen
- Prednisolone, 6alpha-methyl-
- Prednisolone, methyl-
- Prednol- L
- Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6alpha,11beta)-
- Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-
- Promacortine
- Reactenol
- Sieropresol
- Solomet
- Summicort
- Suprametil
- U 7532
- U-67,590A
- UNII-X4W7ZR7023
- Urbason
- Urbasone
- Wyacort
Systematic Names
- Methylprednisolone
- Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6alpha,11beta)-
- Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
- Pregna-1,4-diene-3,20-dione, 6-alpha-methyl-11-beta-17,21-trihydroxy-
Registry Numbers
CAS Registry Number
- 83-43-2
FDA UNII
- X4W7ZR7023
Other Registry Numbers
- 121673-01-6
- 570-35-4
System Generated Number
- 0000083432
Structure Descriptors
InChI
InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1InChIKey
VHRSUDSXCMQTMA-PJHHCJLFSA-NSmiles
C[C@H]1C[C@H]2[C@@H]3CC[C@](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 2292mg/kg (2292mg/kg) | Drugs in Japan Vol. 6, Pg. 832, 1982. | |
rat | LD50 | oral | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 832, 1982. | |
women | TDLo | intravenous | 20mg/kg/45M-C (20mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Journal of Rheumatology. Vol. 13, Pg. 477, 1986. |
women | TDLo | intravenous | 60mg/kg/3D-I (60mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Annals of Internal Medicine. Vol. 99, Pg. 282, 1983. |
women | TDLo | parenteral | 2400ug/kg (2.4mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: CHANGE IN RATE | British Journal of Anesthesia. Vol. 69, Pg. 422, 1992. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 232.5 | deg C | EXP | |
log P (octanol-water) | 1.820 | (none) | EST | |
Water Solubility | 120 | mg/L | 25 | EXP |
Atmospheric OH Rate Constant | 7.39E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.