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Substance Name: Iodoquinol [USAN:USP]
RN: 83-73-8
UNII: 63W7IE88K8
InChIKey: UXZFQZANDVDGMM-UHFFFAOYSA-N

Note

  • One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.

Molecular Formula

  • C9-H5-I2-N-O

Molecular Weight

  • 396.9445
 

Classification Codes

  • Amebicides
  • Anti-Amebic
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data

Names and Synonyms

Name of Substance

  • Diiodohydroxyquin
  • Diiodohydroxyquinoline [INN]
  • Iodoquinol
  • Iodoquinol [USAN:USP]

MeSH Heading

  • Iodoquinol

Synonyms

  • 5,7-Diiod-8-chinolinol
  • 5,7-Diiod-8-chinolinol [IUPAC]
  • 5,7-Diiodo-8-hydroxyquinoline
  • 5,7-Diiodo-8-quinolinol
  • 5,7-Diiodo-oxine
  • 5,7-Diodo-8-quinolinol
  • 5-21-03-00296 (Beilstein Handbook Reference)
  • 8-Hydroxy-5,7-diiodoquinoline
  • 8-Quinolinol, 5,7-diiodo-
  • AI3-16443
  • BRN 0153639
  • Caswell No. 354
  • Di-quinol
  • Diamoebin
  • Diiodohidroxiquinoleina
  • Diiodohidroxiquinoleina [INN-Spanish]
  • Diiodohydroxyquin
  • Diiodohydroxyquinoleine
  • Diiodohydroxyquinoleine [INN-French]
  • Diiodohydroxyquinoline
  • Diiodohydroxyquinolinum
  • Diiodohydroxyquinolinum [INN-Latin]
  • Diiodoidrossichinolina
  • Diiodoidrossichinolina [DCIT]
  • Diiodoquin
  • Dijodoxichinoline
  • Dijodoxichinolinum
  • Dinoleine
  • Diodohydroxyquin
  • Diodoquin
  • Diodoquine
  • Diodoxylin
  • Diodoxyquinoleine
  • Direxiode
  • Disoquin
  • Dyodin
  • EC 201-497-9
  • EINECS 201-497-9
  • Embequin
  • Enterodiamoebin
  • Enterosept
  • EPA Pesticide Chemical Code 024003
  • Floraquin
  • Fluoraquin
  • HSDB 3224
  • Iodoquinol
  • Ioquin
  • Ioquin suspension
  • Lanodoxin
  • Moebiquin
  • NSC 8704
  • Panaquin
  • Quinadome
  • Rafamebin
  • Searlequin
  • Sebaquin
  • SS 578
  • Stanquinate
  • UNII-63W7IE88K8
  • Yodoxin
  • Zoaquin

Systematic Names

  • 8-Quinolinol, 5,7-diiodo-
  • Diiodohydroxyquinoline

Mixture Names

  • Cor-Tar-Quin
  • Vytone

Registry Numbers

CAS Registry Number

  • 83-73-8

FDA UNII

  • 63W7IE88K8

System Generated Number

  • 0000083738

Structure Descriptors

InChI

1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

InChIKey

UXZFQZANDVDGMM-UHFFFAOYSA-N

Smiles

c1cc2c(cc(c(c2nc1)O)I)I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 300mg/kg (300mg/kg) LIVER: OTHER CHANGES American Journal of Tropical Medicine. Vol. 24, Pg. 29, 1944.
child TDLo oral 819mg/kg/13D- (819mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA
Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 113, 1993.
child TDLo oral 120gm/kg/2Y-I (120000mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE Lancet. Vol. 1, Pg. 261, 1966.
guinea pig LDLo oral 50mg/kg (50mg/kg) LIVER: OTHER CHANGES American Journal of Tropical Medicine. Vol. 24, Pg. 29, 1944.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03304,
rat LD oral > 40gm/kg (40000mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 3, Pg. 44, 1948.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 210 deg C   EXP
log P (octanol-water) 4.000 (none)   EST
Atmospheric OH Rate Constant 1.09E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.