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Substance Name: Phenformin hydrochloride [USP]
RN: 834-28-6
UNII: 91XC93EU03
InChIKey: YSUCWSWKRIOILX-UHFFFAOYSA-N

Note

  • A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)

Molecular Formula

  • C10-H15-N5.Cl-H

Molecular Weight

  • 241.7244
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Phenformin hydrochloride [USP]

Synonyms

  • 1-(2-Phenylethyl)biguanide hydrochloride
  • 1-Fenetilbiguanide cloridrato
  • 1-Fenetilbiguanide cloridrato [Italian]
  • 1-Phenethylbiguanide hydrochloride
  • 1-Phenylaethylbiguanid hydrochlorid
  • 1-Phenylaethylbiguanid hydrochlorid [German]
  • 1beta-Phenylethylbiguanide hydrochloride
  • AI3-51271
  • Biguanide, 1-phenethyl-, hydrochloride
  • CCRIS 4857
  • DBI
  • DBI-TD
  • Dipar
  • EINECS 212-637-3
  • Meltrol
  • Meltrol-50
  • N'-beta-Phenethylbiguanide hydrochloride
  • N'-beta-Phenylethylbiguanide-hydrochloride
  • N(sup 1)-beta-Phenethylbiguanide hydrochloride
  • N-beta-Phenylethyl biguanide hydrochloride
  • N-Phenethylbiguanide hydrochloride (VAN)
  • NSC 23100
  • Phenethylbiguanide hydrochloride
  • Phenethylbiguanide hydrochloride (VAN)
  • Phenformin HCl
  • Phenformin HCl No. 9113
  • Phenformin hydrochloride
  • Phenformin, hydrochloride
  • UNII-91XC93EU03
  • USAF VI-6

Systematic Names

  • Biguanide, 1-phenethyl-, monohydrochloride
  • Imidodicarbonimidic diamide, N-(2-phenylethyl)-, monohydrochloride
  • Phenformin hydrochloride

Superlist Name

  • Phenformin hydrochloride

Registry Numbers

CAS Registry Number

  • 834-28-6

FDA UNII

  • 91XC93EU03

Other Registry Number

  • 21228-47-7

System Generated Number

  • 0000834286

Molecular Formulas

Molecular Formula

  • C10-H15-N5.Cl-H

Molecular Formula Fragments

  • C10-H15-N5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

InChIKey

YSUCWSWKRIOILX-UHFFFAOYSA-N

Smiles

c1(CCNC(NC(N)=N)=N)ccccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 47mg/kg (47mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 314, 1962.
guinea pig LD50 subcutaneous 19mg/kg (19mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 314, 1962.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   National Technical Information Service. Vol. AD691-490,
mouse LD50 intravenous 17800ug/kg (17.8mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00094,
mouse LD50 oral 407mg/kg (407mg/kg) ENDOCRINE: HYPOGLYCEMIA Toxicology and Applied Pharmacology. Vol. 14, Pg. 393, 1969.
mouse LDLo subcutaneous 200mg/kg (200mg/kg)   Journal of the American Chemical Society. Vol. 81, Pg. 3728, 1959.
rat LD50 intraperitoneal 140mg/kg (140mg/kg)   Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 36, Pg. 401, 1979.
rat LD50 intravenous 17500ug/kg (17.5mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1571, 1973.
rat LD50 oral 938mg/kg (938mg/kg)   Farmaco, Edizione Scientifica. Vol. 15, Pg. 521, 1960.