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Substance Name: Delapril hydrochloride [USAN:JAN]
RN: 83435-67-0
UNII: 2SMM3M5ZMH
InChIKey: FDJCVHVKXFIEPJ-JCNFZFLDSA-N

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive
  • Drug / Therapeutic Agent
  • Enzyme Inhibitor (Angiotensin-Converting)
  • Enzyme Inhibitors
  • Protease Inhibitors
  • Reproductive Effect

Molecular Formula

  • C26-H32-N2-O5.Cl-H

Molecular Weight

  • 489.009
 
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Names and Synonyms

Name of Substance

  • Delapril
  • Delapril hydrochloride [USAN:JAN]

Synonyms

  • CCRIS 1925
  • CV 3317
  • Delapril HCl
  • Delapril hydrochloride
  • Ethyl (S)-2-(((S)-1-((carboxymethyl)-2-indanylcarbamoyl)ethyl)amino)-4-phenylbutyrate, monohydrochloride
  • Glycine, N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)-, monohydrochloride
  • N-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-N-(indan-2-yl)glycine hydrochloride
  • REV 6000A
  • UNII-2SMM3M5ZMH

Systematic Names

  • Delapril hydrochloride
  • Glycine, N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-, monohydrochloride, (S)-

Registry Numbers

CAS Registry Number

  • 83435-67-0

FDA UNII

  • 2SMM3M5ZMH

Other Registry Number

  • 119543-18-9

System Generated Number

  • 0083435670

Molecular Formulas

Molecular Formula

  • C26-H32-N2-O5.Cl-H

Molecular Formula Fragments

  • C26-H32-N2-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C26H32N2O5.ClH/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22;/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30);1H/t18-,23-;/m0./s1

InChIKey

FDJCVHVKXFIEPJ-JCNFZFLDSA-N

Smiles

C1(N(C([C@@H](N[C@@H](CCc2ccccc2)C(OCC)=O)C)=O)CC(O)=O)Cc2ccccc2C1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 164mg/kg (164mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
mouse LD50 oral 3120mg/kg (3120mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
mouse LD50 subcutaneous 2340mg/kg (2340mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
mouse LD50 subcutaneous 2340mg/kg (2340mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
rat LD50 intraperitoneal 208mg/kg (208mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
rat LD50 oral 8260mg/kg (8260mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
rat LD50 oral 8260mg/kg (8260mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
rat LD50 subcutaneous 5900mg/kg (5900mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,