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Substance Name: Naphazoline [INN:BAN]
RN: 835-31-4
UNII: H231GF11BV
InChIKey: CNIIGCLFLJGOGP-UHFFFAOYSA-N

Note

  • An adrenergic vasoconstrictor agent used as a decongestant.

Molecular Formula

  • C14-H14-N2

Molecular Weight

  • 210.2786
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-Agonists
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Nasal Decongestants
  • Neurotransmitter Agents
  • Respiratory System Agents
  • Vasoconstrictor Agents

Names and Synonyms

Name of Substance

  • Naphazoline
  • Naphazoline [INN:BAN]

MeSH Heading

  • Naphazoline

Synonyms

  • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
  • 2-(1-Naphthylmethyl)-2-imidazoline
  • 2-(alpha-Naphthylmethyl)-imidazoline
  • 2-(Naphthyl-(1')-methyl)imidazolin
  • 2-(Naphthyl-(1')-methyl)imidazolin [German]
  • 4,5-Dihydro-2-(1-naphthylmethyl)imidazole
  • 5-23-08-00293 (Beilstein Handbook Reference)
  • alpha-Naphthylmethyl imidazoline
  • Antan
  • BRN 0151864
  • Ciba 2020/R
  • Clearine
  • EINECS 212-641-5
  • Nafazolina
  • Nafazolina [DCIT]
  • Nafazoline
  • Nafazoline [Spanish]
  • Naphazoline
  • Naphazolinum
  • Naphazolinum [INN-Latin]
  • Naphazolinum [Latin]
  • Naphthizine
  • UNII-H231GF11BV

Systematic Names

  • 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-
  • 2-Imidazoline, 2-(1-naphthylmethyl)-
  • Naphazoline

Registry Numbers

CAS Registry Number

  • 835-31-4

FDA UNII

  • H231GF11BV

Related Registry Number

  • 550-99-2 (mono-hydrochloride)

System Generated Number

  • 0000835314

Structure Descriptors

InChI

1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)

InChIKey

CNIIGCLFLJGOGP-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)cccc2CC3=NCCN3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LDLo intravenous 10mg/kg (10mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 192, Pg. 141, 1939.
mouse LD50 intraperitoneal 62mg/kg (62mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 729, 1979.
mouse LD50 intravenous 170mg/kg (170mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.
mouse LD50 oral 270mg/kg (270mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 729, 1979.
mouse LD50 subcutaneous 514mg/kg (514mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Russian Pharmacology and Toxicology Vol. 37, Pg. 198, 1974.
rabbit LD50 intravenous 800ug/kg (0.8mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.
rabbit LD50 subcutaneous 950ug/kg (0.95mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.
rat LD50 subcutaneous 385mg/kg (385mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.520 (none)   EST
Water Solubility 11.8 mg/L 25 EST
Vapor Pressure 6.67E-08 mm Hg 25 EST
Henry's Law Constant 5.05E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.25E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.