Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Defibrotide sodium [USAN]
RN: 83712-60-1

Note

  • Single-stranded polydeoxyribonucleotide extracted from mammalian organs and used in the treatment of HEPATIC VENO-OCCLUSIVE DISEASE in patients with kidney or lung abnormalities following HEMATOPOIETIC STEM CELL TRANSPLANTATION. The compound is a sodium salt.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Natural Product
  • Platelet Aggregation Inhibitors
  • Treatment of Veno-Occlusive Disease

Names and Synonyms

Results Name

  • Defibrotide sodium [USAN]

Name of Substance

  • Defibrotide
  • Defibrotide sodium [USAN]
  • Defibrotide [INN:BAN]

Synonyms

  • Dasovas
  • Defibrinotide
  • Defibrotide
  • Defibrotide (bovine lung)
  • Defibrotide sodium
  • Defitelio
  • Fraction P
  • JZP-381
  • Noravid
  • Prociclide
  • UNII-438HCF2X0M
  • UNII-L7CHH2B2J0

Systematic Name

  • Defibrotide

Registry Numbers

CAS Registry Number

  • 83712-60-1

FDA UNIIs

  • 438HCF2X0M
  • L7CHH2B2J0

System Generated Number

  • 0083712601

Structure Descriptors

Smiles

[*]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intraperitoneal > 600mg/kg (600mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
dog LD intravenous > 300mg/kg (300mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
dog LD oral > 3600mg/kg (3600mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
mouse LD intraperitoneal > 2280mg/kg (2280mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
mouse LD intravenous > 570mg/kg (570mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
mouse LD oral > 4gm/kg (4000mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
rabbit LD intravenous > 1200mg/kg (1200mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
rat LD intraperitoneal > 2280mg/kg (2280mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
rat LD intravenous > 570mg/kg (570mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.
rat LD oral > 5gm/kg (5000mg/kg)   Cardiovascular Drug Reviews. Vol. 9, Pg. 172, 1991.