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Substance Name: Cetirizine [INN:BAN]
RN: 83881-51-0
UNII: YO7261ME24
InChIKey: ZKLPARSLTMPFCP-UHFFFAOYSA-N
Note
- A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
Molecular Formula
- C21-H25-Cl-N2-O3
Molecular Weight
- 388.8925
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Allergic Agents
- Drug / Therapeutic Agent
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Histamine H1 Antagonists, Non-Sedating
- Neurotransmitter Agents
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Names and Synonyms
Name of Substance
- Cetirizine
- Cetirizine [INN:BAN]
MeSH Heading
- Cetirizine
Synonyms
- (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid
- AC-170
- Cetirizina
- Cetirizina [Spanish]
- Cetirizine
- Cetirizinum
- Cetirizinum [Latin]
- Cetryn
- Hitrizin Film Tablet
- HSDB 7739
- Setir
- UNII-YO7261ME24
- Virlix
- Zerviate
- Ziptek
Systematic Name
- Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
Registry Numbers
CAS Registry Number
- 83881-51-0
FDA UNII
- YO7261ME24
Related Registry Number
- 83881-52-1 (di-hydrochloride)
System Generated Number
- 0083881510
Structure Descriptors
InChI
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)InChIKey
ZKLPARSLTMPFCP-UHFFFAOYSA-NSmiles
OC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | intraperitoneal | 116mg/kg (116mg/kg) | United States Patent Document. Vol. #4525358, |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 112.5 | deg C | EXP | |
| log P (octanol-water) | -0.610 | (none) | EST | |
| Atmospheric OH Rate Constant | 2.41E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.