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Substance Name: Cetirizine hydrochloride [USAN:USP]
RN: 83881-52-1
UNII: 64O047KTOA
InChIKey: PGLIUCLTXOYQMV-UHFFFAOYSA-N

Note

  • A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.

Molecular Formula

  • C21-H25-Cl-N2-O3.2Cl-H

Molecular Weight

  • 461.8143
 

Classification Codes

  • Antihistaminic
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Cetirizine hydrochloride [USAN:USP]

Synonyms

  • (+-)-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid, dihydrochloride
  • (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid dihydrochloride
  • AC-170
  • Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride, (+-)-
  • Alercet
  • Alergex
  • Alerid
  • Alerlisin
  • Alertisin
  • Allergy relief
  • Alleroff
  • Apo-Cetirizine
  • Cetalerg
  • Ceterifug
  • Ceti TAD
  • Ceti-Puren
  • Cetiderm
  • Cetidura
  • Cetil von ct
  • CetiLich
  • Cetirigamma
  • Cetirizin AL
  • Cetirizin AZU
  • Cetirizin Basics
  • Cetirizine Dihydrochloride
  • Cetirizine HCl
  • Cetirizine hydrochloride
  • Cetirizine Hydrochloride Allergy
  • Cetirizine Hydrochloride Hives
  • Cetirlan
  • Cetriler
  • Cetrine
  • Cetzine
  • Cezin
  • Children's Cetirizine hydrochloride allergy
  • Children's Cetirizine hydrochloride hives relief
  • Children's Zyrtec
  • Children's Zyrtec Allergy
  • Children's Zyrtec Hives Relief
  • Formistin
  • P 071
  • P-071
  • Reactine
  • Ressital
  • Riztec
  • Ryzen
  • Salvalerg
  • Setiral
  • Stopaler
  • Sun mark all day allergy
  • Topcare all day allergy
  • Triz
  • UCB-P 071
  • UNII-64O047KTOA
  • Up and up all day allergy relief
  • Virdos
  • Virlix
  • Voltric
  • Xero-sed
  • Zerviate
  • Zetir
  • Zirtek
  • Zirtin
  • Zyrtec
  • Zyrtec Allergy
  • Zyrtec Hives Relief
  • Zyrzine

Systematic Name

  • Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride, (+-)-

Registry Numbers

CAS Registry Number

  • 83881-52-1

FDA UNII

  • 64O047KTOA

Other Registry Number

  • 130018-82-5

Related Registry Number

  • 83881-51-0 (Parent)

System Generated Number

  • 0083881521

Molecular Formulas

Molecular Formula

  • C21-H25-Cl-N2-O3.2Cl-H

Molecular Formula Fragments

  • C21-H25-Cl-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H

InChIKey

PGLIUCLTXOYQMV-UHFFFAOYSA-N

Smiles

Cl.Cl.OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 320mg/kg (320mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 1859, 1994.
mouse LDLo intraperitoneal 138mg/kg (138mg/kg)   United States Patent Document. Vol. #4525358,
rat LD50 oral 365mg/kg (365mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 1859, 1994.