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Substance Name: Chlorproethazine [INN]
RN: 84-01-5
UNII: 960NX27Z07
InChIKey: DBOUGBAQLIXZLV-UHFFFAOYSA-N

Classification Codes

  • Central Nervous System Agents
  • Muscle Relaxants, Central
  • Neuromuscular Agents
  • Peripheral Nervous System Agents

Molecular Formula

  • C19-H23-Cl-N2-S

Molecular Weight

  • 346.9237
 
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Names and Synonyms

Name of Substance

  • Chlorproethazine
  • Chlorproethazine [INN]

Synonyms

  • 2-Chloro-10-(3-diethylaminopropyl)phenothiazine
  • Chlorproethazine
  • Chlorproethazinum
  • Chlorproethazinum [INN-Latin]
  • Clorproetazina
  • Clorproetazina [INN-Spanish]
  • EINECS 201-510-8
  • Neuriplege
  • RP 4909
  • UNII-960NX27Z07

Systematic Names

  • 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-diethyl- (9CI)
  • Chlorproethazine
  • Phenothiazine, 2-chloro-10-(3-(diethylamino)propyl)-

Registry Numbers

CAS Registry Number

  • 84-01-5

FDA UNII

  • 960NX27Z07

Related Registry Number

  • 4611-02-3 (mono-hydrochloride)

System Generated Number

  • 0000084015

Structure Descriptors

InChI

1S/C19H23ClN2S/c1-3-21(4-2)12-7-13-22-16-8-5-6-9-18(16)23-19-11-10-15(20)14-17(19)22/h5-6,8-11,14H,3-4,7,12-13H2,1-2H3

InChIKey

DBOUGBAQLIXZLV-UHFFFAOYSA-N

Smiles

CCN(CC)CCCN1c2ccccc2Sc3c1cc(cc3)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 90mg/kg (90mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 intravenous 16mg/kg (16mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse LD50 oral 300mg/kg (300mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 subcutaneous 325mg/kg (325mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 6.46 (none)   EXP
Water Solubility 0.016 mg/L 25 EST
Vapor Pressure 3.34E-08 mm Hg 25 EST
Henry's Law Constant 6.50E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.60E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.