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Substance Name: Prochlorperazine maleate [USP:JAN]
RN: 84-02-6
UNII: I1T8O1JTL6
InChIKey: DSKIOWHQLUWFLG-SPIKMXEPSA-N

Note

  • A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)

Molecular Formula

  • C20-H24-Cl-N3-S.C4-H4-O4

Molecular Weight

  • 606.0928
 

Classification Codes

  • Anti-Emetic
  • Antipsychotic
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Prochlorperazine maleate [USP:JAN]

Synonyms

  • 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2)
  • 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine, dimaleate
  • 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine dimaleate
  • 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine maleate (1:2)
  • Buccastem
  • Compazine
  • EINECS 201-511-3
  • Emetiral
  • Meterazin maleate
  • Nibromin A
  • Pasotomin
  • Prochloroproazine hydrogen maleate
  • Prochlorperazine bimaleate
  • Prochlorperazine dimaleate
  • Prochlorperazine hydrogen maleate
  • Prochlorperazine maleate
  • Prochlorperazinu dimaleat
  • Prochlorperazinu dimaleat [Czech]
  • Proclorperazine maleate
  • Stemetil dimaleate
  • UNII-I1T8O1JTL6
  • Vertigon

Systematic Names

  • 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2)
  • Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, maleate (1:2)
  • Prochlorperazine maleate

Mixture Name

  • Combid

Registry Numbers

CAS Registry Number

  • 84-02-6

FDA UNII

  • I1T8O1JTL6

System Generated Number

  • 0000084026

Molecular Formulas

Molecular Formula

  • C20-H24-Cl-N3-S.C4-H4-O4

Molecular Formula Fragments

  • C20-H24-Cl-N3-S
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

InChIKey

DSKIOWHQLUWFLG-SPIKMXEPSA-N

Smiles

CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1.OC(=O)\C=C/C(=O)O.OC(=O)\C=C/C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 191mg/kg (191mg/kg)   Psychopharmacologia Vol. 12, Pg. 142, 1968.
mouse LD50 intravenous 85mg/kg (85mg/kg)   Cesko-Slovenska Farmacie. Vol. 12, Pg. 445, 1963.
mouse LD50 subcutaneous 320mg/kg (320mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 40, 1972.
rat LD50 oral 750mg/kg (750mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 78, 1959.
women TDLo intravenous 600ug/kg/18H- (0.6mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Southern Medical Journal. Vol. 84, Pg. 407, 1991.