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Substance Name: Pipamazine [INN:BAN]
RN: 84-04-8
UNII: 653552FH1N
InChIKey: OSJJYEUEJRVVOD-UHFFFAOYSA-N

Classification Code

  • Human Data

Molecular Formula

  • C21-H24-Cl-N3-O-S

Molecular Weight

  • 401.9596
 
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Names and Synonyms

Name of Substance

  • Pipamazine [INN:BAN]

Synonyms

  • 1-(3-(3-Chlorophenothiazin-10-yl)propyl)-isonipecotamide
  • 10-(3-(4-Carbamoylpiperidino)propyl)-2-chlorophenothiazine
  • EINECS 201-512-9
  • Mometine
  • Mornidine
  • Nausidol
  • Nometine
  • Pipamazina
  • Pipamazina [INN-Spanish]
  • Pipamazine
  • Pipamazinum
  • Pipamazinum [INN-Latin]
  • SC 8016
  • SC 9387
  • UNII-653552FH1N

Systematic Names

  • 10-(3-(4-Carbamoylpiperidino)propyl)-2-chlorophenothiazine
  • Isonipecotamide, 1-(3-(2-chlorophenothiazin-10-yl)propyl)-
  • Pipamazine

Registry Numbers

CAS Registry Number

  • 84-04-8

FDA UNII

  • 653552FH1N

System Generated Number

  • 0000084048

Structure Descriptors

InChI

1S/C21H24ClN3OS/c22-16-6-7-20-18(14-16)25(17-4-1-2-5-19(17)27-20)11-3-10-24-12-8-15(9-13-24)21(23)26/h1-2,4-7,14-15H,3,8-13H2,(H2,23,26)

InChIKey

OSJJYEUEJRVVOD-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)N(c3cc(ccc3S2)Cl)CCCN4CCC(CC4)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 500ug/kg (0.5mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 478, 1969.
mouse LD50 intraperitoneal 80mg/kg (80mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 39, 1972.
mouse LD50 oral 370mg/kg (370mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 39, 1972.
rat LD50 oral 620mg/kg (620mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 39, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 139 deg C   EXP
pKa Dissociation Constant 8.6 (none)   EXP
log P (octanol-water) 4.44 (none)   EXP
Water Solubility 0.037 mg/L 25 EST
Vapor Pressure 3.20E-12 mm Hg 25 EST
Henry's Law Constant 5.78E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.77E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.