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Substance Name: Tetrahydrozoline
RN: 84-22-0
UNII: S9U025Y077
InChIKey: BYJAVTDNIXVSPW-UHFFFAOYSA-N

Note

  • Used as nasal decongestant; Visine is a form of eye drops.

Molecular Formula

  • C13-H16-N2

Molecular Weight

  • 200.2834
 

Classification Codes

  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Nasal Decongestants
  • Ophthalmic Solutions
  • Peripheral Nervous System Agents
  • Pharmaceutical Solutions
  • Respiratory System Agents
  • Sympathomimetics
  • Vasoconstrictor Agents

Names and Synonyms

Results Name

  • Tetrahydrozoline

Name of Substance

  • Tetrahydrozoline
  • Tetryzoline [INN:BAN]

Synonyms

  • 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-
  • 5-23-07-00394 (Beilstein Handbook Reference)
  • BRN 0011442
  • EINECS 201-522-3
  • HSDB 7471
  • Tetrahydrozoline
  • Tetrahydrozolinum
  • Tetrizolina
  • Tetrizolina [INN-Spanish]
  • Tetryzolin
  • Tetryzoline
  • Tetryzolinum
  • Tetryzolinum [INN-Latin]
  • Tyzanol
  • UNII-S9U025Y077

Systematic Names

  • 2-Imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)-
  • Tetryzoline

Registry Numbers

CAS Registry Number

  • 84-22-0

FDA UNII

  • S9U025Y077

Other Registry Number

  • 67731-52-6

Related Registry Number

  • 522-48-5 (mono-hydrochloride)

System Generated Number

  • 0000084220

Structure Descriptors

InChI

1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)

InChIKey

BYJAVTDNIXVSPW-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)CCCC2C3=NCCN3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 150ug/kg (0.15mg/kg) BEHAVIORAL: IRRITABILITY

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Annals of Emergency Medicine. Vol. 20, Pg. 655, 1991.
child TDLo oral 186nL/kg (186mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) American Journal of Emergency Medicine. Vol. 2, Pg. 217, 1984.
child TDLo oral 375nL/kg (375mL/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
American Journal of Emergency Medicine. Vol. 2, Pg. 217, 1984.
child TDLo oral 1049nL/kg (1049mL/kg) KIDNEY, URETER, AND BLADDER: INCONTINENCE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Pediatric Emergency Care. Vol. 15, Pg. 193, 1999.
infant TCLo inhalation 60mg/kg (60mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: COMA
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 580, 1969.
mouse LD50 intraperitoneal 116mg/kg (116mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962.
mouse LD50 intravenous 48100ug/kg (48.1mg/kg)   Drugs in Japan Vol. -, Pg. 699, 1990.
mouse LD50 oral 335mg/kg (335mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962.
mouse LD50 subcutaneous 252mg/kg (252mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.690 (none)   EST
Atmospheric OH Rate Constant 8.33E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.